Evidence map›Paper›PMID 34343570›Full record

ArticleExperimental eye research2021

Characterization and allogeneic transplantation of a novel transgenic cone-rich donor mouse line.

Ying V Liu, Derek Teng, Gregory J Konar, Dzhalal Agakishiev, Alexis Biggs-Garcia, Sarah Harris-Bookman, Minda M McNally, Catalina Garzon, Saalini Sastry, Mandeep S Singh

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental eye research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Ying V LiuWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Derek TengWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Gregory J KonarWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Dzhalal AgakishievWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Alexis Biggs-GarciaWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sarah Harris-BookmanWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Minda M McNallyWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Catalina GarzonWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Saalini SastryZanvyl Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, MD, USA.
Mandeep S SinghWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: mandeep@jhmi.edu.
Johns Hopkins University · US

Funding

Wilmer Core Grant for Vision ResearchP30EY001765 · NEI · JOHNS HOPKINS UNIVERSITY · PI Ji Yi · 1985 to 2026
$22.1M
Developing photoreceptor repair for macular degeneration therapy.R01EY033103 · NEI · JOHNS HOPKINS UNIVERSITY · PI SINGH, MANDEEP · 2021 to 2025
$2.0M
NEI NIH HHS P30 EY001765NEI NIH HHS R01 EY033103
6 · The paper itself

Abstract

objectivesCone photoreceptor transplantation is a potential treatment for macular diseases. The optimal conditions for cone transplantation are poorly understood, partly because of the scarcity of cones in donor mice. To facilitate allogeneic cone photoreceptor transplantation studies in mice, we aimed to create and characterize a donor mouse model containing a cone-rich retina with a cone-specific enhanced green fluorescent protein (EGFP) reporter.

methodsWe generated OPN1LW-EGFP/NRL

resultsOPN1LW-EGFP/NRL

conclusionsOPN1LW-EGFP/NRL

Indexed as

Cell TransplantationAnimalsCell LineCone OpsinsElectroretinographyGreen Fluorescent ProteinsMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMicroscopy, Electron, TransmissionOphthalmoscopyRetinaRetinal Cone Photoreceptor CellsRetinal DegenerationRod OpsinsCone Opsinsenhanced green fluorescent proteinGreen Fluorescent Proteinslong-wavelength opsinRod OpsinsAge-related macular degenerationCone photoreceptorCone transplantationDegenerative retinal diseasesOptic coherence tomographyStem cell therapy

Identifiers

PMID34343570
PMCPMC8429259
OpenAlexW3189326460

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.