Evidence map›Paper›PMID 34343536›Full record

ReviewSurvey of ophthalmology

Bacille Calmette-Guérin: An ophthalmic perspective.

Manish Jain, Julie Vadboncoeur, Sunir J Garg, Jyotirmay Biswas

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Survey of ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Manish JainHimalayan Institute of Medical Sciences, Jolly Grant, Dehradun, UK, India.
Julie VadboncoeurDepartment of Ophthalmology, Université de Montréal, Montréal, Uveitis Service, University Ophthalmology Center, Maisonneuve-Rosemont Hospital, Montréal, Canada.
Sunir J GargThomas Jefferson University, Philadelphia, PA USA.
Jyotirmay BiswasDirector of Uveitis & Ocular Pathology Department, Sankara Nethralaya, Chennai, TN, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaccines such as bacille Calmette-Guérin (BCG) are known for their heterologous effects mediated through a number of mechanisms, including trained immunity constituted by monocyte-macrophage based innate immunity. Other events such as direct hematogenous spread and induction of autoimmunity are also described. There has been a resurgent interest in harnessing some of the benefits of trained immunity in the management of COVID-19, even as several specific vaccines have been approved. We summarize the current knowledge of ocular effects of BCG. Potential effect of granulomatous inflammation on angiotensin converting enzyme activity and accentuation of cytokine storm that may result in undesirable ocular and systemic effects are also discussed.

Indexed as

BCG VaccineCOVID-19EyeHumansImmunity, InnateSARS-CoV-2BCG VaccineAdverse drug eventsAngiotensin converting enzymeAutoimmunityBacille Calmette-GuérinCOVID-19EndophthalmitisHeterologous immunitySARS CoV-2trained immunityUveitis

Identifiers

PMID34343536
PMCPMC8325561

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.