ArticleCell metabolism2021
Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca
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Article in Cell metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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54 citing papers in PubMed, 65 citations in OpenAlex.
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- Mitochondrial cristae remodeling: Mechanisms, functions, and pathology.Cell insight · 2025Review
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Authors and funding
26 authors at 12 institutions in 5 countries.
Alicia G Gómez-ValadésNeuronal Control of Metabolism (NeuCoMe) Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain. Electronic address: agarciag@clinic.cat.
Macarena PozoNeuronal Control of Metabolism (NeuCoMe) Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
Luis VarelaProgram in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.
Mehdi Boutagouga BoudjadjaFaculty of Biology, Medicine and Health, School of Medical Sciences, University of Manchester, M13 9PT Manchester, UK.
Sara RamírezNeuronal Control of Metabolism (NeuCoMe) Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
Iñigo ChiviteNeuronal Control of Metabolism (NeuCoMe) Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
Elena EyreNeuronal Control of Metabolism (NeuCoMe) Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
Roberta Haddad-TóvolliNeuronal Control of Metabolism (NeuCoMe) Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
Arnaud ObriNeuronal Control of Metabolism (NeuCoMe) Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
Maria Milà-GuaschNeuronal Control of Metabolism (NeuCoMe) Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
Jordi AltirribaLaboratory of Metabolism, Department of Internal Medicine Specialties, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland.
Marc SchneebergerLaboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
Mónica ImbernónDepartment of Physiology, Centro de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), University of Santiago de Compostela, Instituto de Investigación Sanitaria (IDIS), 15782 Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid, Spain.
Angela R Garcia-RenduelesNeoplasia & Endocrine Differentiation, Centro de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), University of Santiago de Compostela, Instituto de Investigación Sanitaria (IDIS), 15782 Santiago de Compostela, Spain.
Pau Gama-PerezDepartament de Ciències Fisiològiques, Universitat de Barcelona, 08907 Barcelona, Spain; Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), 08908 L'Hospitalet de Llobregat, Spain.
Jonathan Rojo-RuizInstituto de Biología y Genética Molecular (IBGM), Universidad de Valladolid y Consejo Superior de Investigaciones Científicas (CSIC), 47003 Valladolid, Spain.
Bence RáczDepartment of Anatomy and Histology, University of Veterinary Medicine, 1078 Budapest, Hungary.
Maria Teresa AlonsoInstituto de Biología y Genética Molecular (IBGM), Universidad de Valladolid y Consejo Superior de Investigaciones Científicas (CSIC), 47003 Valladolid, Spain.
Ramon GomisDiabetes and Obesity Research Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain; Department of Endocrinology and Nutrition, Hospital Clínic, School of Medicine, University of Barcelona, 08036 Barcelona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain.
Antonio ZorzanoCIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain; Departament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, Spain; Institute for Research in Biomedicine (IRB Barcelona), 08028 Barcelona, Spain.
Giuseppe D'AgostinoFaculty of Biology, Medicine and Health, School of Medical Sciences, University of Manchester, M13 9PT Manchester, UK.
Clara V AlvarezNeoplasia & Endocrine Differentiation, Centro de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), University of Santiago de Compostela, Instituto de Investigación Sanitaria (IDIS), 15782 Santiago de Compostela, Spain.
Rubén NogueirasDepartment of Physiology, Centro de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), University of Santiago de Compostela, Instituto de Investigación Sanitaria (IDIS), 15782 Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid, Spain.
Pablo M Garcia-RovesDepartament de Ciències Fisiològiques, Universitat de Barcelona, 08907 Barcelona, Spain; Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), 08908 L'Hospitalet de Llobregat, Spain.
Tamas L HorvathProgram in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Anatomy and Histology, University of Veterinary Medicine, 1078 Budapest, Hungary.
Marc ClaretNeuronal Control of Metabolism (NeuCoMe) Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain; School of Medicine, Universitat de Barcelona, 08036 Barcelona, Spain. Electronic address: mclaret@clinic.cat.
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESCentro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas · ESInstituto de Biomedicina y Genética Molecular de Valladolid · ESInstituto de Investigación Sanitaria de Santiago · ESUniversidade de Santiago de Compostela · ESUniversitat de Barcelona · ESUniversity of Manchester · GBUniversity of Veterinary Medicine · HUHoward Hughes Medical Institute · USInstitut d'Investigació Biomédica de Bellvitge · ESUniversity of Geneva · CHYale University · US
Funding
The role of AgRP/Auga-ALK pathway in FGF21's brain action on agingP01AG051459 · NIA · YALE UNIVERSITY · PI VISHWA DEEP DIXIT · 2016 to 2026
$25.7MPET imaging of AD-related markers in non-human primatesR01AG052986 · NIA · YALE UNIVERSITY · PI HORVATH, TAMAS L, LAWRENCE, MATTHEW SWAN · 2017 to 2020
$2.9MAgRP neurons promote the effects of calorie restriction on lifespanR01AG052005 · NIA · YALE UNIVERSITY · PI HORVATH, TAMAS L · 2017 to 2021
$2.2MFeeding Driven by POMC NeuronsR01DK111178 · NIDDK · YALE UNIVERSITY · PI HORVATH, TAMAS L · 2017 to 2020
$1.9MIn vivo and in vitro systems to validate geronic proteins and their mechanisms of actionR56AG052986 · NIA · YALE UNIVERSITY · PI HORVATH, TAMAS L, LAWRENCE, MATTHEW SWAN · 2016 to 2016
$494kMedical Research Council MR/P009824/1Medical Research Council MR/P009824/2NIA NIH HHS P01 AG051459NIA NIH HHS R01 AG052005NIA NIH HHS R01 AG052986NIA NIH HHS R56 AG052986NIDDK NIH HHS R01 DK111178
Abstract
Appropriate cristae remodeling is a determinant of mitochondrial function and bioenergetics and thus represents a crucial process for cellular metabolic adaptations. Here, we show that mitochondrial cristae architecture and expression of the master cristae-remodeling protein OPA1 in proopiomelanocortin (POMC) neurons, which are key metabolic sensors implicated in energy balance control, is affected by fluctuations in nutrient availability. Genetic inactivation of OPA1 in POMC neurons causes dramatic alterations in cristae topology, mitochondrial Ca
Indexed as
LipolysisPro-OpiomelanocortinAdipose TissueAnimalsGTP PhosphohydrolasesHomeostasisMiceNeuronsGTP PhosphohydrolasesOpa1 protein, mousePro-OpiomelanocortincristaehypothalamuslipolysismitochondriaobesityOPA-1POMC neurons
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