Evidence map›Paper›PMID 34343276›Full record

ReviewCardiovascular research2021

Cardiac allograft vasculopathy: current review and future research directions.

Jordan S Pober, Sharon Chih, Jon Kobashigawa, Joren C Madsen, George Tellides

Registry-linked trialOpen access · bronzeAbstract readReview
In one paragraph

Review in Cardiovascular research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07020039 (Comparing Photon Counting Computed Tomography With Invasive Coronary Angiography and Intravascular Ultrasound in Detecting Cardiac Allograft Vasculopathy), which is not on this map. Cited by 85 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 1 pooled it
12.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07020039 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Comparing Photon Counting Computed Tomography With Invasive Coronary Angiography and Intravascular Ultrasound in Detecting Cardiac Allograft Vasculopathy

Typeobservational_patient_registrySponsorSahlgrenska University HospitalRan2025 to 2027Enrolled100ConditionsCardiac Allograft Vasculopathy
3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Cardiac Lymphatics Predict Survival After Heart Transplantation.Journal of the American Heart Association · 2026
    Article
  19. Review
  20. How Cytokines Regulate Immune Response Toward Chronic Allograft Rejection?Results and problems in cell differentiation · 2026
    Review

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Jordan S PoberDepartment of Immunobiology, Pathology and Dermatology, Yale School of Medicine, 10 Amistad Street, New Haven CT 06520-8089, USA.
Sharon ChihDivision of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada.
Jon KobashigawaDepartment of Medicine, Cedars-Sinai Smidt Heart Institute, Los Angeles, CA, USA.ORCID 0000-0001-9308-3172
Joren C MadsenDivision of Cardiac Surgery and Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.
George TellidesDepartment of Surgery (Cardiac Surgery), Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-7042-8190
Yale University · USCedars-Sinai Smidt Heart Institute · USMassachusetts General Hospital · USUniversity of Ottawa · CA

Funding

XENOGENIC TOLERANCE IN MICEP01HL018646 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MADSEN, JOREN C · 1985 to 2019
$37.5M
Surgery / Physiology CoreP01HL107205 · NHLBI · YALE UNIVERSITY · PI SIMONS, MICHAEL · 2012 to 2022
$18.8M
Project 3: The Role of Erythropoietin in Kidney Transplant ToleranceP01AI123086 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MADSEN, JOREN C · 2016 to 2020
$10.6M
Mixed chimerism induced tolerance in heart recipients requires donor kidney cotransplantationU01AI131470 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MADSEN, JOREN C · 2017 to 2022
$5.6M
Vascular smooth muscle cell heterogeneity and diseaseR01HL152197 · NHLBI · YALE UNIVERSITY · PI SIMONS, MICHAEL, TELLIDES, GEORGE · 2021 to 2024
$3.3M
STRESS SIGNALING PATHWAYS LINKING ENDOTHELIAL INJURY TO GRAFT ARTERIOSCLEROSISR01HL109420 · NHLBI · YALE UNIVERSITY · PI POBER, JORDAN S · 2012 to 2020
$3.3M
Smooth Muscle Cell Proliferation and Degradative Phenotype in Thoracic Aorta Aneurysm and DissectionR01HL146723 · NHLBI · YALE UNIVERSITY · PI HUMPHREY, JAY D., TELLIDES, GEORGE · 2019 to 2022
$2.9M
Ex Vivo Nanoparticle Drug Delivery Targeted to Human Renal Allograft EndotheliumU01AI132895 · NIAID · YALE UNIVERSITY · PI POBER, JORDAN S, SALTZMAN, W. MARK · 2017 to 2021
$2.2M
NHLBI NIH HHS P01 HL018646NHLBI NIH HHS P01 HL107205NHLBI NIH HHS R01 HL109420NHLBI NIH HHS R01 HL146723NHLBI NIH HHS R01 HL152197NIAID NIH HHS P01 AI123086NIAID NIH HHS U01 AI131470NIAID NIH HHS U01 AI132895NIH HHS R01 AI165879
6 · The paper itself

Abstract

Cardiac allograft vasculopathy (CAV) is a pathologic immune-mediated remodelling of the vasculature in transplanted hearts and, by impairing perfusion, is the major cause of late graft loss. Although best understood following cardiac transplantation, similar forms of allograft vasculopathy occur in other vascularized organ grafts and some features of CAV may be shared with other immune-mediated vasculopathies. Here, we describe the incidence and diagnosis, the nature of the vascular remodelling, immune and non-immune contributions to pathogenesis, current therapies, and future areas of research in CAV.

Indexed as

Adaptive ImmunityAnimalsCoronary Artery DiseaseCoronary VesselsEndothelial CellsGraft RejectionGraft SurvivalHeart TransplantationHumansImmunity, InnateMuscle, Smooth, VascularMyocytes, Smooth MuscleRisk FactorsSignal TransductionTreatment OutcomeVascular Remodelingchronic rejectionendothelial cellsheart transplantationinnate and adaptive immunityvascular smooth muscle cells

Identifiers

PMID34343276
PMCPMC8783389
OpenAlexW3191105691

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.