ArticleBioinformatics (Oxford, England)2021
Mediation analysis for survival data with high-dimensional mediators.
Article in Bioinformatics (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Proteomic Mediators Linking Autoimmune Diseases to Major Adverse Cardiovascular Events: Insights from the UK Biobank.Proteomes · 2026Article
- A multi-omics framework for survival mediation analysis of high-dimensional proteogenomic data.PLoS computational biology · 2026Article
- CoxMDS: multiple data splitting for high-dimensional mediation analysis with survival outcomes in epigenome-wide studies.Briefings in bioinformatics · 2026Article
- Powerful large scale inference in high dimensional mediation analysis.PLoS computational biology · 2026Article
- Metabolic Signatures of Air Pollution and Major Adverse Cardiovascular Events in Patients Undergoing Cardiac Catheterization.JACC. Advances · 2026Article
- Article
- HILAMA: High-dimensional multi-omics mediation analysis with latent confounding.BMC medical research methodology · 2025Article
- Debiased machine learning for ultra-high dimensional mediation analysis.Bioinformatics (Oxford, England) · 2025Article
- Post-selection inference for high-dimensional mediation analysis with survival outcomes.Scandinavian journal of statistics, theory and applications · 2025Article
- High-dimensional mediation analysis for longitudinal mediators and survival outcomes.Briefings in bioinformatics · 2025Article
- Causal Mediation Analysis for Integrating Exposure, Genomic, and Phenotype Data.Annual review of statistics and its application · 2025Article
- Heterogeneous Mediation Analysis for Cox Proportional Hazards Model With Multiple Mediators.Statistics in medicine · 2024Article
- Epigenome-wide mediation analysis of the relationship between psychosocial stress and cardiometabolic risk factors in the Health and Retirement Study (HRS).Clinical epigenetics · 2024Article
- Article
- High-dimensional mediation analysis for continuous outcome with confounders using overlap weighting method in observational epigenetic study.BMC medical research methodology · 2024Article
- High-dimensional quantile mediation analysis with application to a birth cohort study of mother-newborn pairs.Bioinformatics (Oxford, England) · 2024Article
- Model Selection for Exposure-Mediator Interaction.Data science in science · 2024Article
- False discovery rate-controlled multiple testing for union null hypotheses: a knockoff-based approach.Biometrics · 2023Article
- Cancer survival prediction by learning comprehensive deep feature representation for multiple types of genetic data.BMC bioinformatics · 2023Article
- Instrumental variable-based high-dimensional mediation analysis with unmeasured confounders for survival data in the observational epigenetic study.Frontiers in genetics · 2023Article
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Authors and funding
5 authors.
Funding
Abstract
motivationMediation analysis has become a prevalent method to identify causal pathway(s) between an independent variable and a dependent variable through intermediate variable(s). However, little work has been done when the intermediate variables (mediators) are high-dimensional and the outcome is a survival endpoint. In this paper, we introduce a novel method to identify potential mediators in a causal framework of high-dimensional Cox regression.
resultsWe first reduce the data dimension through a mediation-based sure independence screening method. A de-biased Lasso inference procedure is used for Cox's regression parameters. We adopt a multiple-testing procedure to accurately control the false discovery rate when testing high-dimensional mediation hypotheses. Simulation studies are conducted to demonstrate the performance of our method. We apply this approach to explore the mediation mechanisms of 379 330 DNA methylation markers between smoking and overall survival among lung cancer patients in The Cancer Genome Atlas lung cancer cohort. Two methylation sites (cg08108679 and cg26478297) are identified as potential mediating epigenetic markers. AVAILABILITY AND IMPLEMENTATION: Our proposed method is available with the R package HIMA at https://cran.r-project.org/web/packages/HIMA/. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.