ArticleBrain : a journal of neurology2021
Interictal spikes with and without high-frequency oscillation have different single-neuron correlates.
Article in Brain : a journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed.
- Internal and external validation of comprehensive high-frequency activity biomarkers for epilepsy surgery.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Article
- Inroads into epilepsy through high-frequency oscillations: Achievements and benchmark areas for improvement.Epilepsia · 2026Review
- Spike-fast activity interplay: A gateway to seizure.Epilepsia · 2026Article
- Toward Unified Biomarkers for Focal Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Multistage sleep recordings: a missing piece in the puzzle of human interictal single-neuron dynamics.Brain communications · 2026Article
- Opposing interictal dynamics in Alzheimer's disease and epilepsy.Progress in neurobiology · 2026Article
- Internal and External Validation of Comprehensive High-Frequency Activity Biomarkers for Epilepsy Surgery.medRxiv : the preprint server for health sciences · 2025Article
- Not All Spikes Are Equal.Journal of clinical medicine · 2025Review
- Investigation of the relationship between 0.5-1200 Hz signal characteristics of cortical high-frequency oscillations and epileptogenicity through multivariate analysis.Epilepsy & behavior reports · 2025Article
- Localization of the Epileptogenic Zone Using Neural Spatial Volatility in Epilepsy Surgery.Neurology · 2025Observational
- Theta-phase locking of single neurons during human spatial memory.Nature communications · 2025Article
- Normative high-frequency oscillation phase-amplitude coupling and effective connectivity under sevoflurane.Brain communications · 2025Article
- Practical measurements distinguishing physiological and pathological stereoelectroencephalography channels based on high-frequency oscillations in the human brain.Epilepsia open · 2024Article
- Spike ripples localize the epileptogenic zone best: an international intracranial study.Brain : a journal of neurology · 2024Article
- Article
- High frequency oscillations in relation to interictal spikes in predicting postsurgical seizure freedom.Scientific reports · 2023Article
- Passive and active markers of cortical excitability in epilepsy.Epilepsia · 2023Review
- Interictal spikes in Alzheimer's disease: Preclinical evidence for dominance of the dentate gyrus and cholinergic control by the medial septum.Neurobiology of disease · 2023Article
- Optimizing detection and deep learning-based classification of pathological high-frequency oscillations in epilepsy.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023Article
- Flexible, high-resolution cortical arrays with large coverage capture microscale high-frequency oscillations in patients with epilepsy.Epilepsia · 2023Article
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Abstract
Interictal epileptiform discharges (IEDs) are a widely used biomarker in patients with epilepsy but lack specificity. It has been proposed that there are truly epileptogenic and less pathological or even protective IEDs. Recent studies suggest that highly pathological IEDs are characterized by high-frequency oscillations (HFOs). Here, we aimed to dissect these 'HFO-IEDs' at the single-neuron level, hypothesizing that the underlying mechanisms are distinct from 'non-HFO-IEDs'. Analysing hybrid depth electrode recordings from patients with temporal lobe epilepsy, we found that single-unit firing rates were higher in HFO- than in non-HFO-IEDs. HFO-IEDs were characterized by a pronounced pre-peak increase in firing, which coincided with the preferential occurrence of HFOs, whereas in non-HFO-IEDs, there was only a mild pre-peak increase followed by a post-peak suppression. Comparing each unit's firing during HFO-IEDs to its baseline activity, we found many neurons with a significant increase during the HFO component or ascending part, but almost none with a decrease. No such imbalance was observed during non-HFO-IEDs. Finally, comparing each unit's firing directly between HFO- and non-HFO-IEDs, we found that most cells had higher rates during HFO-IEDs and, moreover, identified a distinct subset of neurons with a significant preference for this IED subtype. In summary, our study reveals that HFO- and non-HFO-IEDs have different single-unit correlates. In HFO-IEDs, many neurons are moderately activated, and some participate selectively, suggesting that both types of increased firing contribute to highly pathological IEDs.
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