ArticleGlobal spine journal2021
Pattern of Drug Resistance in Primary Spinal Tuberculosis: A Single-Center Study From India.
Article in Global spine journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Global and Regional Patterns of Drug Resistance and Treatment Regimens in Spinal Tuberculosis: A Systematic Review and Meta-Analysis.Global spine journal · 2026Review
- Recommendations of the International Consensus Meeting (ICM) 2025 on Spinal Infections: Part B Tubercular Spondylodiscitis.Global spine journal · 2026Article
- Treatment Outcome of Drug-Resistant Skeletal Tuberculosis: A Retrospective Analysis.Indian journal of orthopaedics · 2024Article
- Multidrug-resistant tuberculosis of spine diagnosis and management: An institutional experience of 21 cases.Surgical neurology international · 2024Article
- Trends and prospects in spinal tuberculosis research: a future-oriented approach.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023Article
- Incidence and Patterns of Drug Resistance in Patients with Spinal Tuberculosis: a Prospective, Single-Center Study from a Tuberculosis-Endemic Country.Indian journal of orthopaedics · 2023Article
- A high proportion of caseous necrosis, abscess, and granulation tissue formation in spinal tuberculosis.Frontiers in microbiology · 2023Article
- Isolated Posterior Instrumentation for Selected Cases of Thoracic and Lumbar Spinal Tuberculosis without Radical Debridement.Zeitschrift fur Orthopadie und Unfallchirurgie · 2022Article
- Tuberculosis of the spine and drug resistance: a review article.Neurosurgical review · 2022Review
- Severe Kyphotic Deformity Involving Thoracolumbar Region -A Management Dilemma.Journal of orthopaedic case reports · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
STUDY
designRetrospective observational analysis.
objectivesSpinal tuberculosis accounts for about 50% of cases among extra pulmonary osteoarticular tuberculosis. Resistance to drugs in spinal tuberculosis patients is on a rise and there is inadequate literature concentrating on the precise pattern of resistance in Indian subcontinent which harbors 24% of global prevalence. The aim was to study the pattern of drug resistance in spinal tuberculosis among first- and second-line drugs. Drug resistance is common in spinal tuberculosis and we intended to find the prevalence of various drug resistance patterns.
methodsPatients with spinal tuberculosis visiting a tertiary center were assessed. Samples were taken from the affected vertebrae and sent for BACTEC mycobacterium growth indicator tube (MGIT) 960 culture. Patients with a positive growth in MGIT were included in the study. All previously treated patients (relapse, treatment after failure, treatment after loss to follow-up and other previously treated patients) were excluded.
resultsA total of 150 patients with a positive growth in MGIT report were included in the study, of whom 43 patients had some kind of drug resistance. Seven were multidrug resistant (MDR), 9 had preextensive drug resistance (pre-XDR), and 4 had extensive drug resistance (XDR). Seventeen patients had mono-drug resistance, which was most frequently for isoniazid. Resistance among second-line drugs was common in the fluoroquinolone group.
conclusionDrug resistance in spinal tuberculosis was found to be 28.6%. Of these, MDR was in 16.2%, pre-XDR in 20.9%, and XDR in 9.3% patients.
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