ArticleBreast cancer research and treatment2021
Risk factors for breast cancer subtypes among Black women undergoing screening mammography.
Article in Breast cancer research and treatment, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Tumor Characteristics and Event Free Survival in Older and Younger Women with Early Breast Cancer.Current oncology (Toronto, Ont.) · 2026Article
- First mammogram-detected cancers portend worse survival in young women diagnosed with breast cancer.Breast cancer research and treatment · 2025Article
- Mammographic density and breast cancer risk among Black American women.International journal of cancer · 2025Article
- Spatial N-glycomics of the normal breast microenvironment reveals fucosylated and high-mannose N-glycan signatures related to BI-RADS density and ancestry.Glycobiology · 2024Article
- Reproductive characteristics, menopausal status, race and ethnicity, and risk of breast cancer subtypes defined by ER, PR and HER2 status: the Breast Cancer Etiology in Minorities study.Breast cancer research : BCR · 2024Article
- Racial differences in weight perception among Black and White women diagnosed with breast cancer.Journal of cancer survivorship : research and practice · 2024Article
- Identifying factors that indicate the possibility of non-visible cases on mammograms using mammary gland content ratio estimated by artificial intelligence.Frontiers in oncology · 2024Article
- Stromal heterogeneity may explain increased incidence of metaplastic breast cancer in women of African descent.Nature communications · 2023Article
- Concomitant analyses of intratumoral microbiota and genomic features reveal distinct racial differences in breast cancer.NPJ breast cancer · 2023Article
- The Role of Safety-Net Hospitals in Reducing Disparities in Breast Cancer Care.Annals of surgical oncology · 2022Review
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
purposeBlack women are more likely than non-Hispanic White women to be diagnosed with triple negative breast cancer (TNBC), an aggressive subtype with limited treatment options. The study objective was to evaluate the associations of known breast cancer risk factors, including breast density, with TNBC among Black women.
methodsThis study included Black women who underwent screening mammography between the ages of 40-84 years at a University of Pennsylvania Health System between 2010 and 2015. Cox proportional hazard models using multiple imputation with chained equations were used to estimate hazard ratios and 95% confidence intervals for risk factors for ER/PR+/HER2- and TNBC.
resultsAmong 25,013 Black women, there were 330 incident breast cancers (1.3%) during a mean follow-up of 5.8 years; 218 (66.1%) ER/PR+ HER- and 61 (18.1%) TNBC. Having dense breasts (heterogeneously dense or extremely dense) vs. non-dense breasts (almost entirely fatty or scattered areas of fibroglandular density) increased risk of ER/PR+/HER2- breast cancer almost 80% (HR 1.79, 95% CI 1.32-2.43) and TNBC more than twofold (HR 2.53, 1.45-4.44). Older age was associated with an increased risk for ER/PR+/HER2- (HR 1.04, 1.03-1.06) and TNBC (HR 1.03, 1.00-1.05). Having a BMI of > 30 kg/m
conclusionOur results suggest that breast density and obesity are strong risk factors for TNBC among Black women. Understanding breast cancer subtype specific risk factors among Black women can help improve risk assessment.
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