Evidence map›Paper›PMID 34342752›Full record

ReviewCurrent oncology reports2021

Next-Generation Immunotherapy Approaches in Melanoma.

Tyler Buchanan, Afsaneh Amouzegar, Jason J Luke

Abstract readReview
In one paragraph

Review in Current oncology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tyler BuchananDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Afsaneh AmouzegarDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Jason J LukeDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. lukejj@upmc.edu.ORCID 0000-0002-1182-4908

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHN C. BYRD · 1988 to 2026
$158.0M
NCI ET-CTN with Phase i Emphasis at UPCIUM1CA186690 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHN C. BYRD, Farshid Dayyani · 2014 to 2026
$9.1M
NCI NIH HHS P30 CA047904
6 · The paper itself

Abstract

purpose of reviewFor patients with metastatic melanoma, immune checkpoint inhibition has drastically changed outcomes. Here, we review the current and next generations of immune-based anti-cancer therapeutics for patients with metastatic melanoma. RECENT

findingsThe need for new anti-cancer therapeutics in patients with metastatic melanoma who have progression of disease despite immune checkpoint blockade is evident. Several novel agents are expected to have FDA approval within the next few years, as they have yielded impressive responses. Despite these optimistic agents, the field of immuno-oncology continues to expand and produce agents with novel mechanisms of action. The next generation of immunotherapy is based upon years of thoroughly researched immuno-oncology. Many of these agents are currently being evaluated in early phase clinical trials, and much of the preliminary data looks promising.

Indexed as

Cell- and Tissue-Based TherapyCytokinesHumansImmune Checkpoint InhibitorsImmune Checkpoint ProteinsImmunity, InnateImmunotherapyMelanomaT-LymphocytesToll-Like ReceptorsCytokinesImmune Checkpoint InhibitorsImmune Checkpoint ProteinsToll-Like ReceptorsCell therapyCheckpointsCytokinesDevelopmental therapeuticsImmunotherapyInnate immunity

Identifiers

PMID34342752
PMCPMC11552657

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.