Evidence map›Paper›PMID 34342678›Full record

SynthesisEuropean journal of pediatrics2022

Proadrenomedullin and neonatal sepsis: a systematic review and meta-analysis of diagnostic accuracy.

Gerasimos Panagiotis Milas, Vasileios Issaris

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European journal of pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Gerasimos Panagiotis MilasParos Public Medical Center, Imittou 78, 15235, Vrilissia, Athens, Greece. jerrymilas@gmail.com.ORCID http://orcid.org/0000-0002-6794-1302
Vasileios IssarisParos Public Medical Center, Imittou 78, 15235, Vrilissia, Athens, Greece.
Athens Medical Center · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The association of proadrenomedullin and neonatal sepsis has been examined in numerous studies. The object of our meta-analysis is to evaluate differences in proadrenomedullin among neonates with sepsis and health neonates. We systematically searched the following databases: MEDLINE, Clinicaltrials.gov, Cochrane Central Register of Controlled Trials (CENTRAL), Google Scholar, and WHO (International Clinical Trials Register Platform) using a structured algorithm. Statistical analysis was conducted using Revman 5.3 and R software. Included studies in the meta-analysis were assessed using the Newcastle-Ottawa scale. Proadrenomedullin levels were found significantly higher in neonates with sepsis than healthy neonates with an SMD equal with 3.07 [95% CI 1.71, 4.42 (p < 10

Indexed as

Neonatal SepsisSepsisAdrenomedullinHumansInfant, NewbornProspective StudiesProtein PrecursorsAdrenomedullinproadrenomedullinProtein PrecursorsClinical sepsisCulture-proven sepsisNeonatal sepsisProadrenomedullin

Identifiers

PMID34342678
OpenAlexW3188720818

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.