ArticleJournal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie2022
Standardized assessment of bone micromorphometry around teeth following orthodontic tooth movement : A µCT split-mouth study in mice.
Article in Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- The NLRP3 Inflammasome Regulates Orthodontic Tooth Movement.Orthodontics & craniofacial research · 2026Article
- Periodontal ligament and alveolar bone remodeling during long orthodontic tooth movement analyzed by a novel user-independent 3D-methodology.Scientific reports · 2023Article
- Correlations between radiological and histological findings of bone remodelling and root resorption in a rodent cleft model.Head & face medicine · 2022Article
- Dynamic changes in tooth displacement and bone morphometry induced by orthodontic force.Scientific reports · 2022Article
- 3D quantification of in vivo orthodontic tooth movement in rats by means of micro-computed tomography.Clinical oral investigations · 2022Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
purposeVolumetric quantitative analyses of bone micromorphometry changes following orthodontic tooth movements are hardly standardizable. The present study aimed at validating and applying a novel microcomputed tomography (CT)-based approach that enables the segmentation of teeth and definition of a standardized volume of interest (VOI) around the roots to assess local bone micromorphometry.
methodsThe jaws of 3 untreated and 14 orthodontically treated mice (protraction of the upper right molar for 11 days with 0.5 N; untreated left upper molar) were scanned with a micro-CT. The first molars and the alveolar bone were segmented, and a standardized VOI was defined around the teeth. The bone volume per total volume (BV/TV) was assessed within the VOI, and BV/TV values were compared between contralateral sites in both untreated (method validation) and treated animals (method application).
resultsThe intraclass correlation coefficient of 0.99 revealed high reliability of the method. In the untreated animals, Bland-Altman analysis confirmed comparable BV/TV fractions (mean difference: -1.93, critical difference: 1.91, Wilcoxon: p = 0.03). In the orthodontically treated animals, BV/TV values were significantly lower at the test compared to the control site (test: 33.23% ± 5.74%, control: 41.33% ± 4.91%, Wilcoxon: p < 0.001).
conclusionWithin the limits of the study, the novel approach demonstrated the applicability to evaluate bone micromorphometry around teeth subjected to orthodontic treatment.
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