Evidence map›Paper›PMID 34342637›Full record

ArticleRadiation research2022

A Trans-Agency Workshop on the Pathophysiology of Radiation-Induced Lung Injury.

David R Cassatt, Alex Gorovets, Banu Karimi-Shah, Rosemary Roberts, Paul W Price, Merriline M Satyamitra, Nushin Todd, Sue-Jane Wang, Libero Marzella

Open access · greenAbstract read
In one paragraph

Article in Radiation research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Anti-Ceramide ScFv Prophylaxis for First Responders to a Limited Nuclear Attack.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2024
    Article
  5. Article
  6. Radiation-induced multi-organ injury.International journal of radiation biology · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

David R CassattRadiation and Nuclear Countermeasures Program (RNCP), National Institutes of Health (NIH), Rockville, Maryland.
Alex GorovetsCenter for Drug Evaluation and Research (CDER), Food and Drug Administration (FDA), Silver Spring, Maryland.
Banu Karimi-ShahCenter for Drug Evaluation and Research (CDER), Food and Drug Administration (FDA), Silver Spring, Maryland.
Rosemary RobertsCenter for Drug Evaluation and Research (CDER), Food and Drug Administration (FDA), Silver Spring, Maryland.
Paul W PriceOffice of Regulatory Affairs, Division of Allergy, Immunology and Transplantation (DAIT), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Rockville, Maryland.
Merriline M SatyamitraRadiation and Nuclear Countermeasures Program (RNCP), National Institutes of Health (NIH), Rockville, Maryland.
Nushin ToddCenter for Drug Evaluation and Research (CDER), Food and Drug Administration (FDA), Silver Spring, Maryland.
Sue-Jane WangCenter for Drug Evaluation and Research (CDER), Food and Drug Administration (FDA), Silver Spring, Maryland.
Libero MarzellaCenter for Drug Evaluation and Research (CDER), Food and Drug Administration (FDA), Silver Spring, Maryland.
Center for Drug Evaluation and Research · USNational Institutes of Health · US

Funding

Intramural NIH HHS Z99 AI999999
6 · The paper itself

Abstract

Research and development of medical countermeasures (MCMs) for radiation-induced lung injury relies on the availability of animal models with well-characterized pathophysiology, allowing effective bridging to humans. To develop useful animal models, it is important to understand the clinical condition, advantages and limitations of individual models, and how to properly apply these models to demonstrate MCM efficacy. On March 20, 2019, a meeting sponsored by the Radiation and Nuclear Countermeasures Program (RNCP) within the National Institute of Allergy and Infectious Diseases (NIAID) brought together medical, scientific and regulatory communities, including academic and industry subject matter experts, and government stakeholders from the Food and Drug Administration (FDA) and the Biomedical Advanced Research and Development Authority (BARDA), to identify critical research gaps, discuss current clinical practices for various forms of pulmonary damage, and consider available animal models for radiation-induced lung injury.

Indexed as

Lung InjuryRadiation InjuriesAnimalsLungModels, AnimalNational Institute of Allergy and Infectious Diseases (U.S.)United States

Identifiers

PMID34342637
PMCPMC9648426
OpenAlexW3191092495

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.