ArticleTranslational vision science & technology2021
Optical Coherence Tomography Angiography-Derived Flux As a Measure of Physiological Changes in Retinal Capillary Blood Flow.
Article in Translational vision science & technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- OCT Angiography of Chorioretinal Microvasculature in Children with Type 1 and Type 2 Diabetes without Retinopathy.Ophthalmology science · 2026Article
- The Association of Retinal Capillary Density and Retinal Thickness in Diabetic Retinopathy.Investigative ophthalmology & visual science · 2025Article
- OCTA Biomarkers Underlying Structure-Function Correlations in Idiopathic Epiretinal Membrane: A Systematic Review.Diagnostics (Basel, Switzerland) · 2025Review
- Quantitative assessment of retinal microvasculature using optical coherence tomography angiography and correlation with visual acuity in leber's hereditary optic neuropathy.International ophthalmology · 2025Observational
- Aging affects retinal oxygen and blood flow metrics in mice.Experimental eye research · 2025Article
- Deep learning segmentation of periarterial and perivenous capillary-free zones in optical coherence tomography angiography.Journal of biomedical optics · 2025Article
- Differential artery-vein analysis in OCTA for predicting the anti-VEGF treatment outcome of diabetic macular edema.Biomedical optics express · 2025Article
- OCTA-ReVA: an open-source toolbox for comprehensive retinal vessel feature analysis in optical coherence tomography angiography.Biomedical optics express · 2024Article
- Differential Capillary and Large Vessel Analysis Improves OCTA Classification of Diabetic Retinopathy.Investigative ophthalmology & visual science · 2024Article
- Differential artery-vein analysis improves the OCTA classification of diabetic retinopathy.Biomedical optics express · 2024Article
- Retinal perfusion is linked to cognition and brain MRI biomarkers in Black Americans.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Article
- An open-source deep learning network AVA-Net for arterial-venous area segmentation in optical coherence tomography angiography.Communications medicine · 2023Article
- Normalized Blood Flow Index in Optical Coherence Tomography Angiography Provides a Sensitive Biomarker of Early Diabetic Retinopathy.Translational vision science & technology · 2023Article
- OCTA Derived Vessel Skeleton Density Versus Flux and Their Associations With Systemic Determinants of Health.Investigative ophthalmology & visual science · 2022Article
- OCT and OCT Angiography Offer New Insights and Opportunities in Schizophrenia Research and Treatment.Frontiers in digital health · 2022Article
- Optical Coherence Tomography Angiography: Considerations Regarding Diagnostic Parameters.Journal of ophthalmic & vision researchArticle
- OCT Angiography-Derived Retinal Capillary Perfusion Measures in the Framingham Heart Study.Ophthalmology scienceArticle
- Differences in Retinal and Choroidal Microvasculature and Structure in Dementia With Lewy Bodies Compared With Normal Cognition.Journal of vitreoretinal diseasesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Purpose: To compare optical coherence tomography angiography (OCTA)-derived flux with conventional OCTA measures of retinal vascular density in assessment of physiological changes in retinal blood flow. Methods: Healthy subjects were recruited, and 3 × 3-mm2 fovea-centered scans were acquired using commercially available swept-source OCTA (SS-OCTA) while participants were breathing room air, 100% O2, or 5% CO2. Retinal perfusion was quantified using vessel area density (VAD) and vessel skeleton density (VSD), as well as novel measures of retinal perfusion, vessel area flux (VAF) and vessel skeleton flux (VSF). Flux is proportional to the number of red blood cells moving through a vessel segment per unit time. The percentage change in each measure was compared between the O2 and CO2 gas conditions for images of all vessels (arterioles, venules, and capillaries) and capillary-only images. Statistical significance was determined using paired t-tests and a linear mixed-effects model. Results: Eighty-four OCTA scans from 29 subjects were included (age, 45.9 ± 19.5 years; 14 male, 48.3%). In capillary-only images, the change under the CO2 condition was 168% greater in VAF than in VAD (P = 0.002) and 124% greater in VSF than in VSD (P = 0.004). Similarly, under the O2 condition, the change was 94% greater in VAF than in VAD (P = 0.004) and 57% greater in VSF than in VSD (P = 0.01). Flux measures showed significantly greater change in capillary-only images compared with all-vessels images. Conclusions: OCTA-derived flux measures quantify physiological changes in retinal blood flow at the capillary level with a greater effect size than conventional vessel density measures. Translational Relevance: OCTA-derived flux is a useful measure of subclinical changes in retinal capillary perfusion.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.