ArticleeLife2021
Physiological and motion signatures in static and time-varying functional connectivity and their subject identifiability.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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Who cites it
34 citing papers in PubMed.
- Methylphenidate differentially alters corticostriatal connectivity after traumatic brain injury.Brain : a journal of neurology · 2025Trial
- When Can Brain Connectivity Track the Working Mind? A Large-Scale Benchmark of Dynamic Functional Connectivity Across Cognitive Paradigms.bioRxiv : the preprint server for biology · 2026Article
- Reorganization of Human Brain Waves Across Diverse States of Consciousness.bioRxiv : the preprint server for biology · 2026Article
- System identification and surrogate data analyses imply approximate Gaussianity and non-stationarity of resting-brain dynamics.bioRxiv : the preprint server for biology · 2026Article
- A low-variance subspace underlies individual differences in resting state fMRI.bioRxiv : the preprint server for biology · 2026Article
- The ASPIRE Research Institute Dataset: Building a Foundation for Brain Health Research in the United Arab Emirates.Scientific data · 2026Article
- Investigating the Variability of Physiological Response Functions across Individuals and Brain Regions in Functional Magnetic Resonance Imaging.Brain topography · 2025Article
- Associations Between Age, Heart Rate Variability, and BOLD fMRI Signal Variability.bioRxiv : the preprint server for biology · 2025Article
- From gradients to cognition: linking cortical manifolds to brain flexibility and disorder.Frontiers in cognition · 2025Review
- Global signal regression reduces connectivity patterns related to physiological signals and does not alter EEG-derived connectivity.Frontiers in neuroimaging · 2025Article
- Brain connectivity correlates of breathing and cardiac patterns in epilepsy: A study including SUDEP cases.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Multimodal state-dependent connectivity analysis of arousal and autonomic centers in the brainstem and basal forebrain.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Article
- Cortical timescales and the modular organization of structural and functional brain networks.Human brain mapping · 2024Article
- Article
- Functional MRI signals exhibit stronger covariation with peripheral autonomic measures as vigilance decreases.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Discovering individual fingerprints in resting-state functional connectivity using deep neural networks.Human brain mapping · 2024Article
- Intermediately synchronised brain states optimise trade-off between subject specificity and predictive capacity.Communications biology · 2023Article
- Deep-learning-enabled brain hemodynamic mapping using resting-state fMRI.NPJ digital medicine · 2023Article
- Comparing the test-retest reliability of resting-state functional magnetic resonance imaging metrics across single band and multiband acquisitions in the context of healthy aging.Human brain mapping · 2023Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Human brain connectivity yields significant potential as a noninvasive biomarker. Several studies have used fMRI-based connectivity fingerprinting to characterize individual patterns of brain activity. However, it is not clear whether these patterns mainly reflect neural activity or the effect of physiological and motion processes. To answer this question, we capitalize on a large data sample from the Human Connectome Project and rigorously investigate the contribution of the aforementioned processes on functional connectivity (FC) and time-varying FC, as well as their contribution to subject identifiability. We find that head motion, as well as heart rate and breathing fluctuations, induce artifactual connectivity within distinct resting-state networks and that they correlate with recurrent patterns in time-varying FC. Even though the spatiotemporal signatures of these processes yield above-chance levels in subject identifiability, removing their effects at the preprocessing stage improves identifiability, suggesting a neural component underpinning the inter-individual differences in connectivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.