ArticleeLife2021
The role of ventromedial prefrontal cortex in reward valuation and future thinking during intertemporal choice.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 53 citations in OpenAlex.
- Augmenting extinction with counterconditioning strengthens and sustains neural safety representations in PTSD.Translational psychiatry · 2026Article
- Ventromedial prefrontal cortex attenuates the link between physiological heart rate reactions to unfairness and value computations in normative decision making.Social cognitive and affective neuroscience · 2026Article
- Investigating hierarchical control among functional networks disrupted by opioid use disorder using effective connectivity.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Motivational neurobehavioral abnormalities under a naturalistic goal-conflict task in patients with premenstrual dysphoric disorder.Frontiers in psychiatry · 2026Article
- Associations Between Steep Delay Discounting and Punishment Learning.Computational psychiatry (Cambridge, Mass.) · 2026Article
- Active information sampling in health and disease.Neuroscience and biobehavioral reviews · 2025Review
- The role of vmPFC in accessing the temporality of life events for mental time travel.Scientific reports · 2025Article
- Dorsomedial and ventromedial prefrontal cortex lesions differentially impact social influence and temporal discounting.PLoS biology · 2025Article
- Validation and Application of Functions of Future Thinking Scale in Chinese Adults.PsyCh journal · 2025Article
- Anhedonia: Current and future treatments.PCN reports : psychiatry and clinical neurosciences · 2025Review
- Delay discounting predicts COVID-19 vaccine booster willingness.Cognitive research: principles and implications · 2025Article
- A framework for uniting space and time in the mind and brain.Frontiers in cognition · 2025Article
- Predictors of Change in Vaccination Decisions Among the Vaccine Hesitant: Examining the Roles of Age and Intolerance of Uncertainty.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2024Article
- Human ventromedial prefrontal cortex is necessary for prosocial motivation.Nature human behaviour · 2024Article
- Assessing the relationship between delay discounting and decisions to engage in various protective behaviors during COVID-19.Cognitive research: principles and implications · 2024Article
- Maturation of cortical input to dorsal raphe nucleus increases behavioral persistence in mice.eLife · 2024Article
- Anhedonia and Depressive Disorders.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2023Review
- Temporal Construal Effects Are Independent of Episodic Future Thought.Psychological science · 2023Article
- Multivariate analysis differentiates intertemporal choices in both value and cognitive control network.Frontiers in neuroscience · 2023Article
- Economic and social values in the brain: evidence from lesions to the human ventromedial prefrontal cortex.Frontiers in neurology · 2023Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 4 countries.
Funding
Abstract
Intertemporal choices require trade-offs between short-term and long-term outcomes. Ventromedial prefrontal cortex (vmPFC) damage causes steep discounting of future rewards (delay discounting [DD]) and impoverished episodic future thinking (EFT). The role of vmPFC in reward valuation, EFT, and their interaction during intertemporal choice is still unclear. Here, 12 patients with lesions to vmPFC and 41 healthy controls chose between smaller-immediate and larger-delayed hypothetical monetary rewards while we manipulated reward magnitude and the availability of EFT cues. In the EFT condition, participants imagined personal events to occur at the delays associated with the larger-delayed rewards. We found that DD was steeper in vmPFC patients compared to controls, and not modulated by reward magnitude. However, EFT cues downregulated DD in vmPFC patients as well as controls. These findings indicate that vmPFC integrity is critical for the valuation of (future) rewards, but not to instill EFT in intertemporal choice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.