ArticleAIDS (London, England)2022
Predictors of secondary HIV transmission risk in a cohort of adolescents living with HIV in South Africa.
Article in AIDS (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Psychosocial Factors Influencing the Sexual Risk Behaviour of Adolescents Living with and Affected by HIV Who Reside in HIV-Affected Homes in Uganda.AIDS and behavior · 2026Article
- Determinants of Antiretroviral Treatment Adherence Among Young Mothers Living with HIV: The Role of Early Motherhood.AIDS and behavior · 2026Article
- HIV self-testing and HIV nondisclosure to male sexual partners among adolescent girls and young women living with HIV in semi-rural northern Uganda: a cross-sectional study.AIDS research and therapy · 2025Article
- Drivers of onward HIV transmission risk among adolescent boys growing up with HIV: a longitudinal cohort study.BMJ public health · 2025Article
- The trend, prevalence and potential risk factors of secondary HIV transmission among HIV/AIDS individuals receiving ART in Guangxi, China: a longitudinal cross-sectional study.Emerging microbes & infections · 2024Article
- Are social protection and food security accelerators for adolescents to achieve the Global AIDS targets?Journal of the International AIDS Society · 2024Article
- Retrospective review of maternal HIV viral load electronic gatekeeping codes in South Africa.Southern African journal of HIV medicine · 2024Article
- Identifying Adolescents at Highest Risk of ART Non-adherence, Using the World Health Organization-Endorsed HEADSS and HEADSS+ Checklists.AIDS and behavior · 2024Article
- Lessons From Implementing Ask-Boost-Connect-Discuss, a Peer-Delivered Psychosocial Intervention for Young Mothers Living With HIV in Malawi, Tanzania, Uganda, and Zambia.Global health, science and practice · 2023Article
- Factors Associated with Preferences for Long-Acting Injectable Antiretroviral Therapy Among Adolescents and Young People Living with HIV in South Africa.AIDS and behavior · 2023Article
- Sexual Behaviour and Attitudes towards Safe Sex of Youth Receiving Antiretroviral Care at Public Health Facilities in Palapye District, Botswana.International journal of environmental research and public health · 2023Article
- The role of structural factors for preventing HIV risk practices among adolescents in South Africa: A three-wave analysis of caregiving, education, food security, and social protection.Research square · 2023Article
- Article
- Social effects of HIV disclosure, an ongoing challenge in young adults living with perinatal HIV: a qualitative study.Frontiers in public health · 2023Article
- HIV status disclosure to male sexual partners and predictors among young women living with HIV in rural Uganda: a cross-sectional study.Therapeutic advances in reproductive healthArticle
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
objectivePreventing secondary HIV transmission from adolescents and young people living with HIV (AYPLHIV) to their partners and children is critical to interrupting the HIV infection cycle in sub-Saharan Africa. We investigated predictors of secondary HIV transmission risk (past-year sexual risk combined with past-year viremia) among AYPLHIV in South Africa.
designA prospective cohort of AYLPHIV in South Africa recruited n = 1046 participants in 2014-2015, 93.6% of whom were followed up in 2016-2017 (1.5% mortality). Questionnaires used validated scales where available and biomarkers were extracted from n = 67 health facilities.
methodsMultivariate logistic regressions tested baseline factors associated with secondary HIV transmission risk, controlling for covariates, with marginal effect modelling combinations.
resultsAbout 14.2% of AYPLHIV reported high secondary HIV transmission risk. High-risk AYPLHIV were more likely to be sexually infected [adjusted odds ratio (aOR) 2.79, 95% confidence interval (95% CI) 1.66-4.68, P < 0.001], and report hunger (aOR 1.93, 95% CI 1.18-3.14, P = 0.008) and substance use (aOR 2.19, 95% CI 1.19-4.02, P = 0.012). They were more likely to be in power-inequitable relationships (aOR 1.77, 95% CI 1.08-2.92, P = 0.025) and be parents (aOR 4.30, 95% CI 2.16-8.57, P < 0.001). Adolescents reporting none of these factors had a 4% probability of secondary transmission risk, rising to 89% probability with all five identified factors. Older age and early sexual debut were also strongly associated with a higher risk of secondary HIV transmission.
conclusionIt is essential to identify and support AYPLHIV at a high risk of secondary transmission. Screening for factors such as mode of infection and parenthood during routine healthcare visits could help identify and provide resources to the most at-risk adolescents.
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