Evidence map›Paper›PMID 34342281›Full record

ArticleActa crystallographica. Section D, Structural biology2021

Structural studies of complexes of kallikrein 4 with wild-type and mutated forms of the Kunitz-type inhibitor BbKI.

Mi Li, Jaroslav Srp, Michael Mareš, Alexander Wlodawer, Alla Gustchina

Open access · greenAbstract read
In one paragraph

Article in Acta crystallographica. Section D, Structural biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Drug Discovery Strategies for Kallikrein-Related Peptidases.International journal of molecular sciences · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Mi LiCenter for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
Jaroslav SrpInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, 166 10 Prague, Czech Republic.ORCID 0000-0003-0223-2326
Michael MarešInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, 166 10 Prague, Czech Republic.
Alexander WlodawerCenter for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.ORCID 0000-0002-5510-9703
Alla GustchinaCenter for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.ORCID 0000-0002-3565-7462
Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry · CZNational Cancer Institute · USLeidos (United States) · US

Funding

CCR NIH HHS HHSN261200800001CEuropean Regional Development Fund CZ.02.1.01/0.0/0.0/16_019/0000729NCI NIH HHS HHSN261200800001EÚstav organické chemie a biochemie Akademie věd České republiky RVO 61388963
6 · The paper itself

Abstract

Structures of BbKI, a recombinant Kunitz-type serine protease inhibitor from Bauhinia bauhinioides, complexed with human kallikrein 4 (KLK4) were determined at medium-to-high resolution in four crystal forms (space groups P3

Indexed as

BauhiniaKallikreinsMutationPlant ProteinsProtein Bindingkallikrein 4KallikreinsPlant ProteinsBauhinia bauhinioidesBbKIchymotrypsinhuman kallikrein 4kallikreinsplant Kunitz inhibitorsproteasesprotein–protein interactionstrypsin

Identifiers

PMID34342281
PMCPMC8329858
OpenAlexW3189634276

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.