Evidence map›Paper›PMID 34342009›Full record

ArticleAlcoholism, clinical and experimental research2021

Sociodemographic and clinical factors associated with transdermal alcohol concentration from the SCRAM biosensor among persons living with and without HIV.

Veronica L Richards, Yiyang Liu, Jessica Orr, Robert F Leeman, Nancy P Barnett, Kendall Bryant, Robert L Cook, Yan Wang

Open access · greenAbstract read
In one paragraph

Article in Alcoholism, clinical and experimental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Veronica L RichardsDepartment of Epidemiology, University of Florida, Gainesville, Florida, USA.ORCID 0000-0002-1391-0607
Yiyang LiuDepartment of Epidemiology, University of Florida, Gainesville, Florida, USA.
Jessica OrrDivision of Infectious Diseases, University of Miami, Miami, Florida, USA.
Robert F LeemanDepartment of Health Education and Behavior, University of Florida, Gainesville, Florida, USA.ORCID 0000-0002-7003-8907
Nancy P BarnettBrown University School of Public Health, Providence, Rhode Island, USA.ORCID 0000-0001-9634-8287
Kendall BryantNational Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA.
Robert L CookDepartment of Epidemiology, University of Florida, Gainesville, Florida, USA.
Yan WangDepartment of Epidemiology, University of Florida, Gainesville, Florida, USA.ORCID 0000-0001-7265-778X
University of Florida · USBrown University · USNational Institute on Alcohol Abuse and Alcoholism · USUniversity of Miami · USYale University · US

Funding

Role of oxidized linoleic acid metabolites in the pathogenesis of alcoholic liver diseaseP20GM113226 · NIGMS · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2016 to 2025
$24.1M
Pharmacotherapy for alcohol consumptionin HIV-infected women: randomized trialU01AA020797 · NIAAA · UNIVERSITY OF FLORIDA · PI COHEN, RONALD A, COOK, ROBERT L · 2011 to 2021
$7.2M
Mechanisms of Behavior Change Resource Core for Alcohol-HIV InterventionsU24AA022003 · NIAAA · BROWN UNIVERSITY · PI KAHLER, CHRISTOPHER W. · 2012 to 2020
$5.9M
Southern HIV and Alcohol Research Consortium Administrative and Research Support CoreU24AA022002 · NIAAA · UNIVERSITY OF FLORIDA · PI COOK, ROBERT L · 2012 to 2022
$5.5M
Administrative Supplement Role of Gut Microbial Dysbiosis in Aging on HIV-associated in the Development of Alzheimer's DiseaseAssociated Dementia (ADRD).U01AA026225 · NIAAA · UNIVERSITY OF LOUISVILLE · PI BARVE, SHIRISH S, COOK, ROBERT L · 2017 to 2021
$3.4M
Translational Science Training to Reduce the Impact of Alcohol on HIV InfectionT32AA025877 · NIAAA · UNIVERSITY OF FLORIDA · PI Robert L Cook, DEBRA E LYON · 2018 to 2026
$3.3M
Mobile Combined Alcohol and HIV Prevention Including PrEP Uptake/Adherence for High-Risk Young MenUH3AA026214 · NIAAA · UNIVERSITY OF FLORIDA · PI LEEMAN, ROBERT F · 2019 to 2021
$1.1M
Laboratory and field validation of a wrist worn alcohol biosensor among persons living with HIVR21AA027191 · NIAAA · UNIVERSITY OF FLORIDA · PI WANG, YAN · 2018 to 2019
$416k
NIAAA NIH HHS R21 AA027191NIAAA NIH HHS T32 AA025877NIAAA NIH HHS U01 AA020797NIAAA NIH HHS U01 AA026225NIAAA NIH HHS U24 AA022002NIAAA NIH HHS U24 AA022003NIAAA NIH HHS UH3AA02614NIAAA NIH HHS UH3 AA026214NIGMS NIH HHS P20 GM113226
6 · The paper itself

Abstract

backgroundTransdermal alcohol biosensors can objectively monitor alcohol use by measuring transdermal alcohol concentration (TAC). However, it is unclear how sociodemographic and clinical factors that influence alcohol metabolism are associated with TAC. The main aim of this study was to examine how sociodemographic factors (sex, age, race/ethnicity) and clinical factors (body mass index, liver enzymes: alanine aminotransferase [ALT] and aspartate transaminase [AST]), alcohol use disorder, and HIV status were associated with TAC while controlling for level of alcohol use.

methodsWe analyzed data from a prospective study involving contingency management for alcohol cessation among persons living with and without human immunodeficiency virus (HIV) that used the Secure Continuous Remote Alcohol Monitoring (SCRAM) biosensor. Forty-three participants (M

resultsNumber of drinks per drinking day (B = 0.29, p < 0.01) and elevated AST (B = 0.50, p = 0.01) were significant predictors of peak TAC. Positive HIV status, female sex, elevated AST, and number of drinks per drinking day were positively associated with TAC-AUC at the bivariate level, whereas only self-reported alcohol use (B = 0.85, p < 0.0001) and female sex (B = 0.67, p < 0.05) were significant predictors of TAC-AUC at the multivariate level.

conclusionsHIV status was not independently associated with TAC. Future studies should consider the sex and liver function of the participant when using alcohol biosensors to measure alcohol use.

Indexed as

Biosensing TechniquesAgedAge FactorsAlanine TransaminaseAlcohol AbstinenceAlcohol DrinkingAlcoholismArea Under CurveAspartate AminotransferasesBody Mass IndexCentral Nervous System DepressantsEthanolEthnicityFemaleHIV InfectionsHumansAlanine TransaminaseAspartate AminotransferasesCentral Nervous System DepressantsEthanolbiosensorheavy drinkingHIVSCRAMtransdermal alcohol concentration

Identifiers

PMID34342009
PMCPMC8526382
OpenAlexW3189660793

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.