Evidence map›Paper›PMID 34341952›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2022

Quantitative myocardial perfusion SPECT/CT for the assessment of myocardial tracer uptake in patients with three-vessel coronary artery disease: Initial experiences and results.

Sebastian Lehner, Isabel Nowak, Mathias Zacherl, Julia Brosch-Lenz, Maximilian Fischer, Harun Ilhan, Johannes Rübenthaler, Astrid Gosewisch, Peter Bartenstein, Andrei Todica

Open access · hybridAbstract read
In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Diagnosis of diffuse ischemia with SPECT relative perfusion imaging: How to eat soup with a fork?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  3. Review of cardiovascular imaging in the Journal of Nuclear Cardiology 2022: single photon emission computed tomography.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Sebastian LehnerDepartment of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität, Munich, Germany. sebastian.r.lehner@icloud.com.
Isabel NowakDepartment of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität, Munich, Germany.
Mathias ZacherlDepartment of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität, Munich, Germany.
Julia Brosch-LenzDepartment of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität, Munich, Germany.
Maximilian FischerDepartment of Internal Medicine, Cardiology, University Hospital, Ludwig-Maximilians-Universität, Munich, Germany.
Harun IlhanDepartment of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität, Munich, Germany.
Johannes RübenthalerDepartment of Radiology, Ludwig-Maximilians-University, Munich, Germany.
Astrid GosewischDepartment of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität, Munich, Germany.
Peter BartensteinDepartment of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität, Munich, Germany.
Andrei TodicaDepartment of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität, Munich, Germany.
Ludwig-Maximilians-Universität München · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo evaluate quantitative myocardial perfusion SPECT/CT datasets for routine clinical reporting and the assessment of myocardial tracer uptake in patients with severe TVCAD.

methodsMPS scans were reconstructed as quantitative SPECT datasets using CTs from internal (SPECT/CT, Q_INT) and external (PET/CT, Q_EXT) sources for attenuation correction. TPD was calculated and compared to the TPD from non-quantitative SPECT datasets of the same patients. SUV

resultsQuantitative reconstruction was feasible. TPD showed an excellent correlation between quantitative and non-quantitative SPECT datasets. SUV

conclusionsAbsolute quantification of myocardial tracer uptake is feasible. The method seems to be robust and principally suitable for routine clinical reporting. Quantitative SPECT might become a valuable tool for the assessment of severe coronary artery disease in a setting of balanced ischemia, where potentially life-threatening conditions might otherwise go undetected.

Indexed as

Coronary Artery DiseaseMyocardial Perfusion ImagingHumansPerfusionPositron Emission Tomography Computed TomographySingle Photon Emission Computed Tomography Computed TomographyTomography, Emission-Computed, Single-Photonattenuation correctionbalanced ischemiaMyocardial perfusion scintigraphyquantitative SPECTthree-vessel disease

Identifiers

PMID34341952
PMCPMC9553851
OpenAlexW3187254860

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.