ArticleAnnals of biomedical engineering2021
Elastic, Dynamic Viscoelastic and Model-Derived Fibril-Reinforced Poroelastic Mechanical Properties of Normal and Osteoarthritic Human Femoral Condyle Cartilage.
Article in Annals of biomedical engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Cationic Tantalum Oxide Nanoparticle and Neutral Iodixanol Contrast Agents Alter Cartilage Mechanical Properties.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Interstitial Fluid Load Support in Human Articular Cartilage: Effects of Degeneration, Loading, and Material Properties via Combined Experimental Testing and Computational Modeling.Annals of biomedical engineering · 2026Article
- Degeneration dependent changes in human knee cartilage mechanical properties revealed by synchrotron tomography based finite element modeling.Osteoarthritis and cartilage open · 2026Article
- Exploring mechanisms governing cartilage interstitial fluid load support in lubrication through experimental and computational analysis.Scientific reports · 2026Article
- Depth-Wise Changes in Tibial and Femoral Human Knee Joint Cartilage at Different Severities of Osteoarthritis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Engineering biomimetic zonal properties in fibre-reinforced hydrogels for functional cartilage tissue engineeringMaterials today. Bio · 2025Article
- Orientation-Independent T2 Mapping Enhances MRI-Based Cartilage Characterization.Annals of biomedical engineering · 2025Article
- Biomechanical effects of medial osteoarthritis progression and UKA on knee lateral compartment using fibril-reinforced biphasic material in finite element study.Scientific reports · 2025Article
- Tissue stiffness heterogeneity in the jaw and temporomandibular joint: its impact on tumor metabolism and considerations forFrontiers in physiology · 2025Review
- Relationship between depth-wise refractive index and biomechanical properties of human articular cartilage.Journal of biomedical optics · 2024Article
- Revealing Detailed Cartilage Function Through Nanoparticle Diffusion Imaging: A Computed Tomography & Finite Element Study.Annals of biomedical engineering · 2024Article
- Article
- Intraoperative Acoustic Evaluation of Living Human Knee Cartilage-Comparison with Respect to Cartilage Degeneration and Aging.Cartilage · 2023Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Osteoarthritis (OA) degrades articular cartilage and weakens its function. Modern fibril-reinforced poroelastic (FRPE) computational models can distinguish the mechanical properties of main cartilage constituents, namely collagen, proteoglycans, and fluid, thus, they can precisely characterize the complex mechanical behavior of the tissue. However, these properties are not known for human femoral condyle cartilage. Therefore, we aimed to characterize them from human subjects undergoing knee replacement and from deceased donors without known OA. Multi-step stress-relaxation measurements coupled with sample-specific finite element analyses were conducted to obtain the FRPE material properties. Samples were graded using OARSI scoring to determine the severity of histopathological cartilage degradation. The results suggest that alterations in the FRPE properties are not evident in the moderate stages of cartilage degradation (OARSI 2-3) as compared with normal tissue (OARSI 0-1). Drastic deterioration of the FRPE properties was observed in severely degraded cartilage (OARSI 4). We also found that the FRPE properties of femoral condyle cartilage related to the collagen network (initial fibril-network modulus) and proteoglycan matrix (non-fibrillar matrix modulus) were greater compared to tibial and patellar cartilage in OA. These findings may inform cartilage tissue-engineering efforts and help to improve the accuracy of cartilage representations in computational knee joint models.
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Registered trials
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