Evidence map›Paper›PMID 34341893›Full record

ArticleCerebellum (London, England)2022

Cerebellar Oscillations in Familial and Sporadic Essential Tremor.

Shi-Bing Wong, Yi-Mei Wang, Chih-Chun Lin, Scott Kun Geng, Nora Vanegas-Arroyave, Seth L Pullman, Sheng-Han Kuo, Ming-Kai Pan

Open access · greenAbstract read
In one paragraph

Article in Cerebellum (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Article
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  5. Review
  6. Article
  7. Article
  8. Review
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  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Neurophysiology of cerebellar ataxias and gait disorders.Clinical neurophysiology practice · 2023
    Review
  16. Milestones in Tremor Research: 10 Years Later.Movement disorders clinical practice · 2022
    Review
  17. Essential tremor: Clinical perspectives and pathophysiology.Journal of the neurological sciences · 2022
    Review
  18. Article
  19. Article
  20. The Role of the Cerebellum in Tremor - Evidence from Neuroimaging.Tremor and other hyperkinetic movements (New York, N.Y.) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Shi-Bing WongDepartment of Pediatrics, Taipei Tzu Chi General Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, 23142, Taiwan.
Yi-Mei WangCerebellar Research Center, National Taiwan University Hospital, Yun-Lin Branch, Yun-Lin, 64041, Taipei, Taiwan.
Chih-Chun LinDepartment of Neurology, Columbia University, New York, NY, 10032, USA.
Scott Kun GengDepartment of Computer Science, Columbia University, New York, NY, 10027, USA.
Nora Vanegas-ArroyaveDepartment of Neurology, Baylor College of Medicine, Houston, TX, 77030, USA.
Seth L PullmanDepartment of Neurology, Columbia University, New York, NY, 10032, USA.
Sheng-Han KuoDepartment of Neurology, Columbia University, New York, NY, 10032, USA.
Ming-Kai PanCerebellar Research Center, National Taiwan University Hospital, Yun-Lin Branch, Yun-Lin, 64041, Taipei, Taiwan. emorymkpan@ntu.edu.tw.ORCID http://orcid.org/0000-0001-5535-2714
Columbia University · USBaylor College of Medicine · USNational Taiwan University · TWNational Taiwan University Hospital · TWTzu Chi University · TW

Funding

True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Ami R Zota · 1998 to 2026
$44.7M
Targeting Cerebellar Endoplasmic Reticulum Calcium Handling in Essential TremorR01NS124854 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PHYLLIS L FAUST, Sheng-Han Kuo · 2022 to 2026
$2.9M
Targeting Cerebellar Excitatory Synapses for Tremor ProgressionR01NS118179 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUO, SHENG-HAN · 2020 to 2024
$2.2M
Cerebellar Circuitry in the Pathophysiology of TremorR01NS104423 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUO, SHENG-HAN · 2018 to 2022
$2.0M
Dietary Contribution in Cerebellar AtaxiaR03NS114871 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUO, SHENG-HAN · 2019 to 2020
$162k
NIEHS NIH HHS P30 ES009089NINDS NIH HHS NS104423NINDS NIH HHS NS118179NINDS NIH HHS R01 NS104423NINDS NIH HHS R01 NS118179NINDS NIH HHS R01 NS124854NINDS NIH HHS R03 NS114871
6 · The paper itself

Abstract

Enhanced cerebellar oscillations have recently been identified in essential tremor (ET) patients as a key pathophysiological change. Since ET is considered a heterogeneous group of diseases, we investigated whether cerebellar oscillations differ in ET subtypes (familial vs. sporadic). This study aims to determine cerebellar physiology in familial and sporadic ET. Using surface electroencephalogram, we studied cerebellar physiology in 40 ET cases (n = 22 familial and n = 18 sporadic) and 20 age-matched controls. Both familial and sporadic ET cases had an increase in the intensity of cerebellar oscillations when compared to controls. Interestingly, cerebellar oscillations correlated with tremor severity in familial ET but not in sporadic ET. Our study demonstrated that ET cases have enhanced cerebellar oscillations, and the different relationships between cerebellar oscillations and tremor severity in familial and sporadic ET suggest diverse cerebellar pathophysiology.

Indexed as

Essential TremorCerebellumElectroencephalographyHumansPhysical Therapy ModalitiesTremorCerebellumElectroencephalogramEssential tremorOscillationPhysiologyTremor

Identifiers

PMID34341893
PMCPMC8970339
OpenAlexW3190994084

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.