Evidence map›Paper›PMID 34341845›Full record

SynthesisKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2021

Platelet-rich plasma injections induce disease-modifying effects in the treatment of osteoarthritis in animal models.

Angelo Boffa, Manuela Salerno, Giulia Merli, Laura De Girolamo, Lior Laver, Jérémy Magalon, Mikel Sánchez, Thomas Tischer, Giuseppe Filardo

2 registry-linked trialsAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 49 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 9 pooled it
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05497349 narecruitingnot on this mapstarted 2022, after this paper: background citation

Use of Leukocyte-Rich PRP or Leukocyte-Free PRP in the Treatment of Hip Osteoarthritis. Double-blind Controlled Randomized Clinical Trial

TypeinterventionalSponsorIstituto Ortopedico RizzoliRan2022 to 2026Enrolled230ConditionsHip OsteoarthritisArmsLeukocyte Rich- PRP injection, Leukocyte Poor- PRP injection
NCT06685120 narecruitingnot on this mapstarted 2025, after this paper: background citation

Combined Use of PRP and Hyaluronic Acid for Infiltrative Treatment of Patients With Knee Osteoarthritis - Randomized Controlled Clinical Study

TypeinterventionalSponsorIstituto Ortopedico RizzoliRan2025 to 2029Enrolled288ConditionsOsteo Arthritis KneeArmsPRP + HA injection, PRP injection, HA injection
3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 9 syntheses or guidelines pooled it, 90 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 7 countries.

Angelo BoffaClinica Ortopedica e Traumatologica 2, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Manuela SalernoApplied and Translational Research Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Giulia MerliApplied and Translational Research Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy. giulia.merli@ior.it.ORCID http://orcid.org/0000-0001-7895-5606
Laura De GirolamoOrthopaedic Biotechnology Laboratory, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.
Lior LaverDepartment of Orthopaedics, Hillel Yaffe Medical Center (HYMC), Hadera, Israel.
Jérémy MagalonCell Therapy Laboratory, Hôpital de la Conception, AP-HM, Marseille, France.
Mikel SánchezArthroscopic Surgery Unit, Hospital Vithas Vitoria, Vitoria-Gasteiz, Spain.
Thomas TischerDepartment of Orthopaedic Surgery, University of Rostock, Rostock, Germany.
Giuseppe FilardoApplied and Translational Research Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Istituto Ortopedico Rizzoli · ITHospital Universitario Araba · ESInserm · FRIstituto Ortopedico Galeazzi · ITOspedale regionale di Lugano · CHTechnion – Israel Institute of Technology · ILUniversity of Rostock · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe mechanisms of action and disease-modifying potential of platelet-rich plasma (PRP) injection for osteoarthritis (OA) treatment are still not fully established. The aim of this systematic review of preclinical evidence was to determine if PRP injections can induce disease-modifying effects in OA joints.

methodsA systematic review was performed on animal studies evaluating intra-articular PRP injections as treatment for OA joints. A synthesis of the results was performed investigating the disease-modifying effects of PRP by evaluating studies that compared PRP with OA controls or other injectable products, different PRP formulations or injection intervals, and the combination of PRP with other products. The risk of bias was assessed according to the SYRCLE's tool.

resultsForty-four articles were included, for a total of 1251 animals. The publication trend remarkably increased over time. PRP injections showed clinical effects in 80% and disease-modifying effects in 68% of the studies, attenuating cartilage damage progression and reducing synovial inflammation, coupled with changes in biomarker levels. Evidence is limited on the best PRP formulation, injection intervals, and synergistic effect with other injectables. The risk of bias was low in 40%, unclear in 56%, and high in 4% of items.

conclusionIntra-articular PRP injections showed disease-modifying effects in most studies, both at the cartilage and synovial level. These findings in animal OA models can play a crucial role in understanding mechanism of action and structural effects of this biological approach. Nevertheless, the overall low quality of the published studies warrants further preclinical studies to confirm the positive findings, as well as high-level human trials to demonstrate if these results translate into disease-modifying effects when PRP is used in the clinical practice to treat OA. LEVEL OF EVIDENCE: Level II.

Indexed as

Osteoarthritis, KneePlatelet-Rich PlasmaAnimalsHumansHyaluronic AcidInflammationInjections, Intra-ArticularModels, AnimalTreatment OutcomeHyaluronic AcidCartilageDisease-modifyingInjectionIntra-articularOsteoarthritisPlatelet-rich plasma (PRP)

Identifiers

PMID34341845
OpenAlexW3187176287

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.