Evidence map›Paper›PMID 34341844›Full record

ArticleWorld journal of surgery2021

Impact of Tumor Burden Score on Conditional Survival after Curative-Intent Resection for Hepatocellular Carcinoma: A Multi-Institutional Analysis.

Ahmed N Elfadaly, Diamantis I Tsilimigras, J Madison Hyer, Alessandro Paro, Fabio Bagante, Francesca Ratti, Hugo P Marques, Olivier Soubrane, Vincent Lam, George A Poultsides and 9 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in World journal of surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Ahmed N ElfadalyDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Diamantis I TsilimigrasDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
J Madison HyerDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Alessandro ParoDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Fabio BaganteDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Francesca RattiDepartment of Surgery, Ospedale San Raffaele, Milano, Italy.
Hugo P MarquesDepartment of Surgery, Curry Cabral Hospital, Lisbon, Portugal.
Olivier SoubraneDepartment of Hepatobiliopancreatic Surgery, APHP, Beaujon Hospital, Clichy, France.
Vincent LamDepartment of Surgery, Westmead Hospital, Sydney, Australia.
George A PoultsidesDepartment of Surgery, Stanford University, Stanford, CA, USA.
Irinel PopescuDepartment of Surgery, Fundeni Clinical Institute, Bucharest, Romania.
Sorin AlexandrescuDepartment of Surgery, Fundeni Clinical Institute, Bucharest, Romania.
Guillaume MartelDepartment of Surgery, University of Ottawa, Ottawa, Canada.
Aklile WorknehDepartment of Surgery, University of Ottawa, Ottawa, Canada.
Alfredo GuglielmiDepartment of Surgery, University of Verona, Verona, Italy.
Tom HughDepartment of Surgery, School of Medicine, The University of Sydney, Sydney, Australia.
Luca AldrighettiDepartment of Surgery, Ospedale San Raffaele, Milano, Italy.
Itaru EndoYokohama City University School of Medicine, Yokohama, Japan.
Timothy M PawlikDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA. tim.pawlik@osumc.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe impact of tumor burden score (TBS) on conditional survival (CS) among patients undergoing curative-intent resection of hepatocellular carcinoma (HCC) has not been examined to date.

methodsPatients who underwent liver resection of HCC between 2000 and 2017 were identified from a multi-institutional database. The impact of TBS and other clinicopathologic factors on 3-year conditional survival (CS

resultsAmong 1,040 patients, 263 (25.3%) patients had low TBS, 668 (64.2%) had medium TBS and 109 (10.5%) had high TBS. TBS was strongly associated with OS; 5-year OS was 39.0% among patients with high TBS compared with 61.1% and 79.4% among patients with medium and low TBS, respectively (p < 0.001). While actuarial survival decreased as time elapsed from resection, CS increased over time irrespective of TBS. The largest differences between 3-year actuarial survival and CS

conclusionsCS rates among patients who underwent resection for HCC increased as patients survived additional years, irrespective of TBS. CS estimates can be used to provide important dynamic information relative to the changing survival probability after resection of HCC.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsHepatectomyHumansPrognosisRetrospective StudiesTumor Burden

Identifiers

PMID34341844

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.