Evidence map›Paper›PMID 34341841›Full record

ArticleAnalytical and bioanalytical chemistry2021

Synthesis, LC-MS/MS analysis, and biological evaluation of two vaccine candidates against ticks based on the antigenic P0 peptide from R. sanguineus linked to the p64K carrier protein from Neisseria meningitidis.

Luis Javier González, Pedro E Encinosa Guzmán, Wendy Machado, Satomy Pousa, Alejandro Leyva, Ana Laura Cano Arguelles, Gleysin Cabrera, Luis Ariel Espinosa, Rubén Parra, Rachel Hernández and 13 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical and bioanalytical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 12 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 4 institutions in 4 countries.

Luis Javier GonzálezDepartment of Proteomics, Center for Genetic Engineering and Biotechnology (CIGB), Avenida 31, e/ 158 y 190, Cubanacán, Playa, 10600, Havana, Cuba. luis.javier@cigb.edu.cu.
Pedro E Encinosa GuzmánAnimal Biotechnology Department, Center for Genetic Engineering and Biotechnology (CIGB), Avenida 31, e/ 158 y 190, Cubanacán, Playa, 10600, Havana, Cuba.
Wendy MachadoDepartment of Proteomics, Center for Genetic Engineering and Biotechnology (CIGB), Avenida 31, e/ 158 y 190, Cubanacán, Playa, 10600, Havana, Cuba.
Satomy PousaDepartment of Proteomics, Center for Genetic Engineering and Biotechnology (CIGB), Avenida 31, e/ 158 y 190, Cubanacán, Playa, 10600, Havana, Cuba.
Alejandro Leyva, Unidad de Bioquímica y Proteómica Analítica (UByPA), Institut Pasteur de Montevideo, Mataojo 2020, Montevideo, Uruguay.
Ana Laura Cano ArguellesAnimal Biotechnology Department, Center for Genetic Engineering and Biotechnology (CIGB), Avenida 31, e/ 158 y 190, Cubanacán, Playa, 10600, Havana, Cuba.
Gleysin CabreraDepartment of Proteomics, Center for Genetic Engineering and Biotechnology (CIGB), Avenida 31, e/ 158 y 190, Cubanacán, Playa, 10600, Havana, Cuba.
Luis Ariel EspinosaDepartment of Proteomics, Center for Genetic Engineering and Biotechnology (CIGB), Avenida 31, e/ 158 y 190, Cubanacán, Playa, 10600, Havana, Cuba.
Rubén ParraDepartment of Proteomics, Center for Genetic Engineering and Biotechnology (CIGB), Avenida 31, e/ 158 y 190, Cubanacán, Playa, 10600, Havana, Cuba.
Rachel HernándezDepartment of Proteomics, Center for Genetic Engineering and Biotechnology (CIGB), Avenida 31, e/ 158 y 190, Cubanacán, Playa, 10600, Havana, Cuba.
Yamil Bello SotoAnimal Biotechnology Department, Center for Genetic Engineering and Biotechnology (CIGB), Avenida 31, e/ 158 y 190, Cubanacán, Playa, 10600, Havana, Cuba.
Frank L LedesmaAnimal Biotechnology Department, Center for Genetic Engineering and Biotechnology (CIGB), Avenida 31, e/ 158 y 190, Cubanacán, Playa, 10600, Havana, Cuba.
Marisdania JoglarAnimal Biotechnology Department, Center for Genetic Engineering and Biotechnology (CIGB), Avenida 31, e/ 158 y 190, Cubanacán, Playa, 10600, Havana, Cuba.
Osmany GuirolaBioinformatics, Center for Genetic Engineering and Biotechnology (CIGB), Avenida 31, e/ 158 y 190, Cubanacán, Playa, 10600, Havana, Cuba.
Louise Ulrich KurtLaboratory for Structural and Computational Proteomics, Carlos Chagas Institute, Fiocruz, Rua Professor Algacyr Munhoz Mader, 3775, Ciudade Industrial de Curitiba, Curitiba, Paraná, 81310-020, Brazil.
Paulo C CarvalhoLaboratory for Structural and Computational Proteomics, Carlos Chagas Institute, Fiocruz, Rua Professor Algacyr Munhoz Mader, 3775, Ciudade Industrial de Curitiba, Curitiba, Paraná, 81310-020, Brazil.
Ania CabralesSynthetic Peptides Laboratory, Center for Genetic Engineering and Biotechnology (CIGB), Avenida 31, e/ 158 y 190, Cubanacán, Playa, 10600, Havana, Cuba.
Hilda GaraySynthetic Peptides Laboratory, Center for Genetic Engineering and Biotechnology (CIGB), Avenida 31, e/ 158 y 190, Cubanacán, Playa, 10600, Havana, Cuba.
Vladimir BesadaDepartment of Proteomics, Center for Genetic Engineering and Biotechnology (CIGB), Avenida 31, e/ 158 y 190, Cubanacán, Playa, 10600, Havana, Cuba.
Rosario Durán, Unidad de Bioquímica y Proteómica Analítica (UByPA), Institut Pasteur de Montevideo, Mataojo 2020, Montevideo, Uruguay.
Toshifumi TakaoInstitute for Protein Research, Osaka University, Suita Campus, Osaka, 565, Japan.
Mario Pablo EstradaAnimal Biotechnology Department, Center for Genetic Engineering and Biotechnology (CIGB), Avenida 31, e/ 158 y 190, Cubanacán, Playa, 10600, Havana, Cuba.
Alina Rodríguez-MallonAnimal Biotechnology Department, Center for Genetic Engineering and Biotechnology (CIGB), Avenida 31, e/ 158 y 190, Cubanacán, Playa, 10600, Havana, Cuba. alina.rodriguez@cigb.edu.cu.
Centro de Ingeniería Genética y Biotecnología · CUFundação Carlos Chagas · BRInstituto de Investigaciones Biológicas Clemente Estable · UYProtein Research Foundation · JP

Funding

CYTED CYTED Network INCOGARR (118RT0541)
6 · The paper itself

Abstract

A peptide from the P0 acidic ribosomal protein (pP0) of ticks conjugated to keyhole limpet hemocyanin from Megathura crenulata has shown to be effective against different tick species when used in host vaccination. Turning this peptide into a commercial anti-tick vaccine will depend on finding the appropriate, technically and economically feasible way to present it to the host immune system. Two conjugates (p64K-Cys

Indexed as

AnimalsBacterial Outer Membrane ProteinsChromatography, LiquidElectrophoresis, Polyacrylamide GelHemocyaninsNeisseria meningitidisRabbitsSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationTandem Mass SpectrometryTicksVaccinesBacterial Outer Membrane ProteinsHemocyaninskeyhole-limpet hemocyaninlpdA protein, Neisseria meningitidisVaccinesAnti-tick vaccineConjugation sitesCross-linked peptidesMass spectrometryP0p64K

Identifiers

PMID34341841
PMCPMC8328535
OpenAlexW3191219683

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.