Evidence map›Paper›PMID 34341791›Full record

ArticlebioRxiv : the preprint server for biology2021

Site-specific recognition of SARS-CoV-2 nsp1 protein with a tailored titanium dioxide nanoparticle.

P Agback, T Agback, F Dominguez, E I Frolova, G Seisenbaeva, V Kessler

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

P AgbackDepartment of Molecular Sciences, BioCenter, Swedish University of Agricultural Sciences, Box 7015, SE-75007, Uppsala, Sweden.
T AgbackDepartment of Molecular Sciences, BioCenter, Swedish University of Agricultural Sciences, Box 7015, SE-75007, Uppsala, Sweden.
F DominguezDepartment of Microbiology, University of Alabama at Birmingham, 1720 2nd Ave South Birmingham, AL 35294, USA.
E I FrolovaDepartment of Microbiology, University of Alabama at Birmingham, 1720 2nd Ave South Birmingham, AL 35294, USA.
G SeisenbaevaDepartment of Molecular Sciences, BioCenter, Swedish University of Agricultural Sciences, Box 7015, SE-75007, Uppsala, Sweden.
V KesslerDepartment of Molecular Sciences, BioCenter, Swedish University of Agricultural Sciences, Box 7015, SE-75007, Uppsala, Sweden.

Funding

Mechanistic understanding of SH3 domain-containing protein function in alphavirus replicationR21AI146969 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FROLOV, ILYA V. · 2019 to 2020
$401k
NIAID NIH HHS R21 AI146969
6 · The paper itself

Abstract

The ongoing world-wide Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) pandemic shows the need for new sensing and therapeutic means against the CoV viruses. The SARS-CoV-2 nsp1 protein is important, both for replication and pathogenesis, making it an attractive target for intervention. In recent years nanoparticles have been shown to interact with peptides, ranging in size from single amino acids up to proteins. These nanoparticles can be tailor-made with specific functions and properties including bioavailability. To the best of our knowledge, in this study we show for the first time that a tailored titanium oxide nanoparticle interacts specifically with a unique site of the full-length SARS-CoV-2 nsp1 protein. This can be developed potentially into a tool for selective control of viral protein functions.

Identifiers

PMID34341791
PMCPMC8328058

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.