Evidence map›Paper›PMID 34341784›Full record

ArticleResearch square2021

Impact of natural selection on global patterns of genetic variation, and association with clinical phenotypes, at genes involved in SARS-CoV-2 infection.

Chao Zhang, Anurag Verma, Yuanqing Feng, Marcelo Cardoso Dos Reis Melo, Michael McQuillan, Matthew Hansen, Anastasia Lucas, Joseph Park, Alessia Ranciaro, Simon Thompson and 19 more

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors at 10 institutions in 6 countries.

Chao ZhangUniversity of Pennsylvania.
Anurag VermaPerelman School of Medicine, University of Pennsylvania.
Yuanqing FengUniversity of Pennsylvania.
Marcelo Cardoso Dos Reis MeloUniversity of Pennsylvania.ORCID 0000-0001-6901-1646
Michael McQuillanUniversity of Pennsylvania.
Matthew HansenUniversity of Pennsylvania.
Anastasia LucasUniversity of Pennsylvania.
Joseph ParkPerelman School of Medicine, University of Pennsylvania.ORCID 0000-0002-3313-641X
Alessia RanciaroUniversity of Pennsylvania.
Simon ThompsonUniversity of Pennsylvania.
Meghan RubelUniversity of Pennsylvania.
Michael CampbellHoward University.
William BeggsUniversity of Pennsylvania.
Jibril HirboVanderbilt University School of Medicine.ORCID 0000-0002-8932-7311
Sununguko Wata MpolokaUniversity of Botswana.
Gaonyadiwe George MokoneUniversity of Botswana.
Marcus JonesHuman Longevity (United States).
Thomas NyamboMuhimbili University of Health and Allied Sciences.
Dawit Wolde MeskelAddis Ababa University Department of Microbial Cellular and Molecular Biology.
Guija BelayAddis Ababa University Department of Microbial Cellular and Molecular Biology.
Charles FokunangDepartment of Pharmacotoxicology and Pharmacokinetics, Faculty of Medicine and Biomedical Sciences, The University of Yaoundé I, Yaoundé, Cameroon.
Alfred NjamnshiThe University of Yaoundé I.
Sabah OmarKenya Medical Research Institute.
Scott WilliamsVanderbilt University.ORCID 0000-0002-4835-9544
Daniel RaderPerelman School of Medicine at the University of Pennsylvania.ORCID 0000-0002-9245-9876
Marylyn RitchieUniversity of Pennsylvania.
Cesar de la FuenteUniversity of Pennsylvania.ORCID 0000-0002-2005-5629
Giorgio SirugoUniversity of Pennsylvania.
Sarah TishkoffUniversity of Pennsylvania.
California University of Pennsylvania · USUniversity of Pennsylvania · USAddis Ababa University · ETUniversité de Yaoundé I · CMUniversity of Botswana · BWVanderbilt University · USHoward University · USHuman Longevity (United States) · USKenya Medical Research Institute · KEMuhimbili University of Health and Allied Sciences · TZ

Funding

VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI DOUGLAS J EPSTEIN · 1986 to 2026
$48.3M
Studies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
Rare variants and NHLBI traits in deeply phenotyped cohortsU01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2017 to 2018
$5.6M
Genetic and molecular basis for variation in human skin pigmentationR01AR076241 · NIAMS · CHILDREN'S HOSP OF PHILADELPHIA · PI MARKS, MICHAEL S, OANCEA, ELENA · 2020 to 2024
$5.5M
Bioinformatics Strategies for Genome-Wide Association StudiesR01LM010098 · NLM · UNIVERSITY OF PENNSYLVANIA · PI MOORE, JASON H., WILLIAMS, SCOTT MATTHEW · 2009 to 2023
$5.1M
Integrative Genomics of Body Size and Metabolism in Ethnically Diverse AfricansR01GM113657 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI TISHKOFF, SARAH ANNE · 2015 to 2019
$2.8M
Integrative Genomic Analyses of Human Evolution and Adaptation in AfricaR35GM134957 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI TISHKOFF, SARAH ANNE · 2020 to 2024
$2.7M
Combining chemical and computational tools for predictive models of microbiome communitiesR35GM138201 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI DE LA FUENTE, CESAR · 2020 to 2024
$1.8M
Integrative nutrigenomic and metabolomic analyses of Africans with variable dietsR01DK104339 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI TISHKOFF, SARAH ANNE · 2015 to 2018
$1.4M
NHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL120393NHLBI NIH HHS U01 HL120393NIAMS NIH HHS R01 AR076241NIDDK NIH HHS P30 DK019525NIDDK NIH HHS R01 DK104339NIGMS NIH HHS R01 GM113657NIGMS NIH HHS R35 GM134957NIGMS NIH HHS R35 GM138201NLM NIH HHS R01 LM010098
6 · The paper itself

Abstract

We investigated global patterns of genetic variation and signatures of natural selection at host genes relevant to SARS-CoV-2 infection (

Identifiers

PMID34341784
PMCPMC8328070
OpenAlexW3191083658

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.