ArticleQuantitative imaging in medicine and surgery2021
Can the delayed phase of quantitative contrast-enhanced mammography improve the diagnostic performance on breast masses?
Article in Quantitative imaging in medicine and surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 20 citations in OpenAlex.
- ROI-Based Quantitative Analysis in Contrast-Enhanced Mammography: A Feasibility Study for Reproducible Enhancement Assessment.Diagnostics (Basel, Switzerland) · 2026Article
- How to optimise breast cancer staging with contrast-enhanced mammography: current evidence and clinical implications.Insights into imaging · 2026Review
- Diagnostic value of contrast-enhanced spectral mammography for breast lesions: qualitative and quantitative analyses.Quantitative imaging in medicine and surgery · 2026Article
- Contrast-Enhanced Mammography: Advances, Challenges, and Case-Based Insights.Korean journal of radiology · 2025Review
- Contrast-enhanced mammography: a success story with open issues and fascinating perspectives.European radiology · 2025Article
- Addition of contrast-enhanced mammography enhancement patterns and morphology for differentiating benign from malignant papillary breast lesions.The British journal of radiology · 2025Article
- Lesion Conspicuity in Contrast-Enhanced Mammography: A Retrospective Analysis of Tumor Characteristics.Cancers · 2025Article
- Malignancy risk stratification prediction of BI-RADS 4B calcifications based on contrast-enhanced mammographic features: a multicenter study.Breast cancer research and treatment · 2025Article
- Contrast-enhanced mammography improves patient access to functional breast imaging.Journal of medical imaging and radiation oncology · 2025Review
- Comparative analysis of diagnostic performance of automatic breast ultrasound and spectral mammography as complementary methods to mammography examination.Polish journal of radiology · 2025Article
- The value of contrast-enhanced energy-spectrum mammography combined with clinical indicators in detecting breast cancer in Breast Imaging Reporting and Data System (BI-RADS) 4 lesions.Quantitative imaging in medicine and surgery · 2024Article
- Role of contrast-enhanced mammogram as an adjunct to tomosynthesis in evaluation of circumscribed breast lesions.The British journal of radiology · 2024Article
- Application of the Kaiser score on contrast-enhanced mammography in the differential diagnosis of breast lesions: comparison with breast magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2024Article
- Breast masses with rim enhancement on contrast-enhanced mammography: morphological and enhancement features for diagnosis and differentiation of benign and malignant.The British journal of radiology · 2024Article
- State-of-the-art for contrast-enhanced mammography.The British journal of radiology · 2024Review
- Contrast-enhanced mammography BI-RADS: a case-based approach to radiology reporting.Insights into imaging · 2024Review
- Development and internal validation of a conventional ultrasound-based nomogram for predicting malignant nonmasslike breast lesions.Quantitative imaging in medicine and surgery · 2022Article
- Association between quantitative and qualitative image features of contrast-enhanced mammography and molecular subtypes of breast cancer.Quantitative imaging in medicine and surgery · 2022Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundContrast-enhanced mammography (CEM) is an imaging tool for breast cancer detection. Most quantitative analyses of CEM involve two phases, and it is unknown whether an added delayed phase can improve its diagnostic performance compared to dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). This study aimed to evaluate whether the delayed phase improves the diagnostic performance of CEM in distinguishing malignant and benign masses.
methodsThis prospective study enrolled 111 women with 111 pathologically confirmed breast masses. CEM was performed after the injection of contrast agent between 2-3 minutes (T1, early phase), 4-5 minutes (T2, second phase), and 7-9 minutes (T3, delayed phase). The quantitative enhanced gray value of lesions (LGV) and the lesion to background grey value ratio (LBR) were measured within each phase's corresponding region of interest (ROI). Based on their changes, the kinetic enhancement pattern was assessed among the three phases, and the diagnostic performance was subsequently measured.
resultsThe LGV and LBR of malignant masses were significantly greater than those of benign lesions. The diagnostic performance of LGV and LBR at the delayed phase was consistent with that of the second phase but poorer than that of the early phase. The sensitivity of LGV
conclusionsThe addition of a delayed CEM phase for breast cancer diagnosis yielded limited performance improvement. The quantitative analysis combined with enhancement patterns between the two consecutive phases has great potential to distinguish between malignant and benign lesions.
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