Evidence map›Paper›PMID 34341585›Full record

ArticleNature neuroscience2021

A role for the cortex in sleep-wake regulation.

Lukas B Krone, Tomoko Yamagata, Cristina Blanco-Duque, Mathilde C C Guillaumin, Martin C Kahn, Vincent van der Vinne, Laura E McKillop, Shu K E Tam, Stuart N Peirson, Colin J Akerman and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. A cortical pathway to sleep: Role of long-range inhibition.Clinical and translational medicine · 2026
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  13. Review
  14. The sleep-wake history contributes to rhythmic BMAL1 chromatin binding in the cerebral cortex but not in the liver.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  15. Article
  16. Article
  17. TREK1 Channels Shape Spindle-Like Oscillations, Neuronal Activity, and Short-Term Synaptic Plasticity in Thalamocortical Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  18. Article
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  20. Review

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lukas B KroneDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-5535-7221
Tomoko YamagataSleep and Circadian Neuroscience Institute, University of Oxford, Oxford, UK.
Cristina Blanco-DuqueDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Mathilde C C GuillauminSleep and Circadian Neuroscience Institute, University of Oxford, Oxford, UK.
Martin C KahnDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Vincent van der VinneDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Laura E McKillopDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Shu K E TamSleep and Circadian Neuroscience Institute, University of Oxford, Oxford, UK.
Stuart N PeirsonSleep and Circadian Neuroscience Institute, University of Oxford, Oxford, UK.
Colin J AkermanDepartment of Pharmacology, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-6844-4984
Anna Hoerder-SuabedissenDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-1953-7871
Zoltán MolnárDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK. zoltan.molnar@dpag.ox.ac.uk.ORCID http://orcid.org/0000-0002-6852-6004
Vladyslav V VyazovskiyDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK. vladyslav.vyazovskiy@dpag.ox.ac.uk.ORCID http://orcid.org/0000-0002-4336-6681

Funding

Biotechnology and Biological Sciences Research Council BB/J014427/1Biotechnology and Biological Sciences Research Council BB/S015817/1Medical Research Council G00900901Medical Research Council G0700377Medical Research Council MR/N026039/1Medical Research Council MR/S01134X/1National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/V000977/1Wellcome Trust 098461/Z/12/ZWellcome Trust 106174Wellcome Trust 106174/Z/14/ZWellcome Trust 109059/Z/15/ZWellcome Trust 203971/Z/16/Z
6 · The paper itself

Abstract

Cortical and subcortical circuitry are thought to play distinct roles in the generation of sleep oscillations and global state control, respectively. Here we silenced a subset of neocortical layer 5 pyramidal and archicortical dentate gyrus granule cells in male mice by ablating SNAP25. This markedly increased wakefulness and reduced rebound of electroencephalographic slow-wave activity after sleep deprivation, suggesting a role for the cortex in both vigilance state control and sleep homeostasis.

Indexed as

AnimalsDentate GyrusMaleMiceMice, TransgenicNeocortexNeuronsSleepSynaptosomal-Associated Protein 25WakefulnessSnap25 protein, mouseSynaptosomal-Associated Protein 25

Identifiers

PMID34341585
PMCPMC7612118

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.