Evidence map›Paper›PMID 34341579›Full record

ArticleNature protocols2021

Rapid ex vivo molecular fingerprinting of biofluids using laser-assisted rapid evaporative ionization mass spectrometry.

Vera Plekhova, Lieven Van Meulebroek, Marilyn De Graeve, Alvaro Perdones-Montero, Margot De Spiegeleer, Ellen De Paepe, Emma Van de Walle, Zoltan Takats, Simon J S Cameron, Lynn Vanhaecke

Open access · greenAbstract readEvaluation Study
PubMed Publisher
In one paragraph

Article in Nature protocols, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
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  7. Tributyrin (CoreBiomeFrontiers in nutrition · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Vera Plekhova *Laboratory of Chemical Analysis, Ghent University, Merelbeke, Belgium.
Lieven Van Meulebroek *Laboratory of Chemical Analysis, Ghent University, Merelbeke, Belgium.
Marilyn De GraeveLaboratory of Chemical Analysis, Ghent University, Merelbeke, Belgium.ORCID 0000-0001-6916-401X
Alvaro Perdones-MonteroDepartment of Surgery and Cancer, Imperial College London, London, UK.
Margot De SpiegeleerLaboratory of Chemical Analysis, Ghent University, Merelbeke, Belgium.ORCID 0000-0002-1088-7245
Ellen De PaepeLaboratory of Chemical Analysis, Ghent University, Merelbeke, Belgium.
Emma Van de WalleLaboratory of Chemical Analysis, Ghent University, Merelbeke, Belgium.
Zoltan TakatsDepartment of Surgery and Cancer, Imperial College London, London, UK.
Simon J S CameronSchool of Biological Sciences, Institute for Global Food Security, Queen's University Belfast, Belfast, Northern Ireland, UK.ORCID 0000-0001-9570-135X
Lynn VanhaeckeLaboratory of Chemical Analysis, Ghent University, Merelbeke, Belgium. Lynn.Vanhaecke@UGent.be.ORCID 0000-0003-0400-2188
Ghent University · BEImperial College London · GBQueen's University Belfast · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Of the many metabolites involved in any clinical condition, only a narrow range of biomarkers is currently being used in the clinical setting. A key to personalized medicine would be to extend this range. Metabolic fingerprinting provides a more comprehensive insight, but many methods used for metabolomics analysis are too complex and time-consuming to be diagnostically useful. Here, a rapid evaporative ionization mass spectrometry (REIMS) system for direct ex vivo real-time analysis of biofluids with minor sample pretreatment is detailed. The REIMS can be linked to various laser wavelength systems (such as optical parametric oscillator or CO

Indexed as

Body FluidsHumansLasers, GasLasers, Solid-StateMass SpectrometryMetabolomics

Identifiers

PMID34341579
OpenAlexW3192706457

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.