ArticleNature metabolism2021
Leptin brain entry via a tanycytic LepR-EGFR shuttle controls lipid metabolism and pancreas function.
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Article in Nature metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
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82citing papers in PubMed
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82 citing papers in PubMed, 137 citations in OpenAlex.
- Obesity, Oxidative Stress, and Inflammation in Precocious Puberty: Do All Roads Lead to the Hypothalamus?International journal of molecular sciences · 2026Review
- Metabolic state determines the brain and direct islet effects of liraglutide on enhanced insulin secretion.Diabetologia · 2026Article
- Secretion Patterns of Leptin: A Key Component in the Regulation of Energy Homeostasis and Its Therapeutic Applications.Biomolecules · 2026Review
- Generation of human appetite-regulating neurons and tanycytes from pluripotent stem cells.Cell stem cell · 2026Article
- Tanycytes: bloodhounds of the metabolic brain.Trends in endocrinology and metabolism: TEM · 2026Review
- A synaptoid connectome differentiates tanycytic subpopulations and underlies neuroglial communication and neuroendocrine regulation.Nature communications · 2026Article
- Synergistic Intervention for Obesity: Integrating Central Appetite Regulation and Peripheral Energy Expenditure.Current obesity reports · 2026Review
- Hypothalamic regulation of energy homeostasis: Quo vadis.Reviews in endocrine & metabolic disorders · 2026Review
- The role of tanycytes in the regulation of energy balance.Reviews in endocrine & metabolic disorders · 2026Review
- The Epidermal Growth Factor Receptor (EGFR) as a means of neuro-immune cross-conversation.Journal of neuroinflammation · 2026Review
- Methodological Challenges for Ablation of BMPR1A in Hypothalamic Tanycytes-A Cautionary Tale.FASEB bioAdvances · 2026Article
- Hypothalamic regulation of sepsis-associated anorexia: cytokine and hormonal signalling through AgRP/POMC circuits.EMBO molecular medicine · 2026Review
- Tanycytic degeneration impairs tau clearance and contributes to Alzheimer's disease pathology.Cell press blue · 2026Article
- Compartmentalized VEGF receptor expression in hypothalamic tanycytes reveals a novel non-endothelial axis of VEGF signaling : Tanycytes as a novel non-endothelial target of VEGF signaling.Fluids and barriers of the CNS · 2026Article
- Lipid droplets in astrocytes: Key organelles for CNS homeostasis and disease (Review).International journal of molecular medicine · 2026Review
- Region-Specific Adult Neural Stem Cell Niches of the Mediobasal Hypothalamus and Medulla Oblongata.Stem cell reviews and reports · 2026Review
- The unanticipated role of the glial-associated glucose-6-phosphatase system in brain homeostasis.iScience · 2025Review
- Obesity and Cognitive Function: Leptin Role Through Blood-Brain Barrier and Hippocampus.Molecular neurobiology · 2025Review
- Perspective: rheostasis revisited-hibernation and tanycytes.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2025Review
- Parallel Pathways, Divergent Outcomes: Adipose Tissue-Neural Crosstalk in Depression and Obesity.Journal of clinical medicine · 2025Review
22 more citing papers are in PubMed but not listed here.
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Authors and funding
28 authors at 10 institutions in 5 countries.
Manon DuquenneUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, EGID, DISTALZ, Lille, France.ORCID http://orcid.org/0000-0002-6435-0953
Cintia Folgueira *Universidade de Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain.ORCID http://orcid.org/0000-0003-3803-9149
Cyril Bourouh *Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, CNRS, U1283-UMR 8199-EGID, Lille, France.
Marion Millet *Centre National de la Recherche Scientifique, Université de Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, Strasbourg, France.
Anisia Silva *Institut Cochin, Inserm U1016, CNRS UMR 8104, University Paris Descartes, Sorbonne Paris Cité, Paris, France.ORCID http://orcid.org/0000-0002-5431-6903
Jérôme Clasadonte *Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, EGID, DISTALZ, Lille, France.
Monica ImbernonUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, EGID, DISTALZ, Lille, France.
Daniela FernandoisUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, EGID, DISTALZ, Lille, France.ORCID http://orcid.org/0000-0002-8282-0189
Ines Martinez-CorralUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, EGID, DISTALZ, Lille, France.
Soumya KusumakshiExperimental Pharmacology, Center for Molecular Signaling, Saarland University School of Medicine, Homburg, Germany.
Emilie CaronUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, EGID, DISTALZ, Lille, France.ORCID http://orcid.org/0000-0002-0258-3815
S RasikaUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, EGID, DISTALZ, Lille, France.ORCID http://orcid.org/0000-0001-8733-4641
Eleonora DeligliaUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, EGID, DISTALZ, Lille, France.ORCID http://orcid.org/0000-0002-1721-1387
Nathalie JouyUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, EGID, DISTALZ, Lille, France.
Asturo OishiInstitut Cochin, Inserm U1016, CNRS UMR 8104, University Paris Descartes, Sorbonne Paris Cité, Paris, France.ORCID http://orcid.org/0000-0003-1788-5485
Massimiliano MazzoneLaboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, VIB, Department of Oncology, Leuven, Belgium.ORCID http://orcid.org/0000-0001-8824-4015
Eric TrinquetCisbio Bioassays, Parc Technologique Marcel Boiteux, Codolet, France.
Jan TavernierVIB-UGent Center for Medical Biotechnology, Gent, Belgium.ORCID http://orcid.org/0000-0002-7609-6462
Young-Bum KimDivision of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9471-6330
Stéphane OryCentre National de la Recherche Scientifique, Université de Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, Strasbourg, France.ORCID http://orcid.org/0000-0003-4359-1157
Ralf JockersInstitut Cochin, Inserm U1016, CNRS UMR 8104, University Paris Descartes, Sorbonne Paris Cité, Paris, France.
Markus SchwaningerInstitute for Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany.ORCID http://orcid.org/0000-0002-4510-9718
Ulrich BoehmExperimental Pharmacology, Center for Molecular Signaling, Saarland University School of Medicine, Homburg, Germany.
Ruben NogueirasUniversidade de Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain.ORCID http://orcid.org/0000-0002-9976-9930
Jean-Sébastien AnnicotteUniv. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, CNRS, U1283-UMR 8199-EGID, Lille, France.ORCID http://orcid.org/0000-0002-2109-4849
Stéphane GasmanCentre National de la Recherche Scientifique, Université de Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, Strasbourg, France.ORCID http://orcid.org/0000-0001-8415-1276
Julie DamInstitut Cochin, Inserm U1016, CNRS UMR 8104, University Paris Descartes, Sorbonne Paris Cité, Paris, France.ORCID http://orcid.org/0000-0001-6871-2678
Vincent PrévotUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, EGID, DISTALZ, Lille, France. vincent.prevot@inserm.fr.ORCID http://orcid.org/0000-0001-7185-3615
Inserm · FRCentre National de la Recherche Scientifique · FRInstitut des Neurosciences Cellulaires et Intégratives · FRSaarland University · DEUniversidade de Santiago de Compostela · ESBeth Israel Deaconess Medical Center · USCisbio (France) · FRUniversity of Lübeck · DEVIB-KU Leuven Center for Cancer Biology · BEVIB-UGent Center for Medical Biotechnology · BE
Funding
Role of tanycytic LRP in Aβ clearanceR01DK123002 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KIM, YOUNG-BUM · 2020 to 2023
$2.9MEuropean Research Council 810331NIDDK NIH HHS R01 DK123002
Abstract
Metabolic health depends on the brain's ability to control food intake and nutrient use versus storage, processes that require peripheral signals such as the adipocyte-derived hormone, leptin, to cross brain barriers and mobilize regulatory circuits. We have previously shown that hypothalamic tanycytes shuttle leptin into the brain to reach target neurons. Here, using multiple complementary models, we show that tanycytes express functional leptin receptor (LepR), respond to leptin by triggering Ca
Indexed as
Lipid MetabolismBrainDiabetes MellitusEnergy MetabolismEpendymoglial CellsErbB ReceptorsInsulin-Secreting CellsLeptinPancreasPhosphorylationReceptors, LeptinErbB ReceptorsLeptinReceptors, Leptin
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