Trial reportScientific reports2021
Hidden pandemic: COVID-19-related stress, SLC6A4 methylation, and infants' temperament at 3 months.
Trial report in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Effect of COVID-19 on Pregnancy and Neonate's Vital Parameters: A Systematic Review.Journal of pregnancy · 2023Pooled it
- SLC6A4 Gene Methylation in Premature Infants Undergoing Kangaroo Mother Care: A Prospective Longitudinal Study.Biomedicines · 2026Article
- Disrupted beginnings: Neurodevelopmental outcomes of COVID-19 lockdowns in early childhood (Review).Experimental and therapeutic medicine · 2026Review
- Exploring the relationship betweenFrontiers in psychology · 2026Article
- Prematurity and Epigenetic Regulation ofBiomedicines · 2025Article
- Youth mental health crisis: A translational view of the COVID-19 pandemic.Neurobiology of stress · 2025Review
- Association of maternal psychological distress and milk cortisol with infant temperament and growth.Scientific reports · 2025Article
- Technical considerations for placental tissue processing and the subsequent impact on genome-wide DNA methylation analysis.Clinical epigenetics · 2024Article
- Brain structural and functional outcomes in the offspring of women experiencing psychological distress during pregnancy.Molecular psychiatry · 2024Review
- Epigenetic Responses to Nonchemical Stressors: Potential Molecular Links to Perinatal Health Outcomes.Current environmental health reports · 2024Review
- A preliminary investigation of epigenome-wide DNA methylation and temperament during infancy.Developmental psychobiology · 2024Article
- Epigenetics of prenatal stress in humans: the current research landscape.Clinical epigenetics · 2024Review
- Maternal-prenatal stress and depression predict infant temperament during the COVID-19 pandemic.Development and psychopathology · 2024Article
- Molecular pathways in placental-fetal development and disruption.Molecular and cellular endocrinology · 2024Review
- The impact of maternal mood and economic stress during Covid-19 pandemic on infant behaviour: Findings from the cross-sectional UK Covid-19 New Mum Study.PLOS global public health · 2024Article
- The relationships between the family impact and distress of the coronavirus disease-19 pandemic, parent insomnia, infant temperamental negative affectivity, and parent-reported infant sleep: a path analysis.Sleep advances : a journal of the Sleep Research Society · 2024Article
- Maternal perceived stress and infant behavior during the COVID-19 pandemic.Pediatric research · 2023Article
- Prenatal exposure to environmental air pollution and psychosocial stress jointly contribute to the epigenetic regulation of the serotonin transporter gene in newborns.Molecular psychiatry · 2023Article
- Differences in infant negative affectivity during the COVID-19 pandemic.Infant mental health journal · 2023Article
- STEP-COVID: a pilot study of a prenatal intervention for pregnant women during the COVID-19 pandemic.Scientific reports · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 10 institutions in 1 country.
Funding
Abstract
The COVID-19 pandemic represents a collective trauma that may have enduring stress effects during sensitive periods, such as pregnancy. Prenatal stress may result in epigenetic signatures of stress-related genes (e.g., the serotonin transporter gene, SLC6A4) that may in turn influence infants' behavioral development. In April 2020, we launched a longitudinal cohort study to assess the behavioral and epigenetic vestiges of COVID-19-related prenatal stress exposure in mothers and infants. COVID-19-related prenatal stress was retrospectively assessed at birth. SLC6A4 methylation was assessed in thirteen CpG sites in mothers and infants' buccal cells. Infants' temperament was assessed at 3-month-age. Complete data were available from 108 mother-infant dyads. Greater COVID-19-related prenatal stress was significantly associated with higher infants' SLC6A4 methylation in seven CpG sites. SLC6A4 methylation at these sites predicted infants' temperament at 3 months.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.