Evidence map›Paper›PMID 34341386›Full record

ArticleScientific reports2021

Catestatin in innate immunity and Cateslytin-derived peptides against superbugs.

Francesco Scavello, Angela Mutschler, Sophie Hellé, Francis Schneider, Sylvette Chasserot-Golaz, Jean-Marc Strub, Sarah Cianferani, Youssef Haikel, Marie-Hélène Metz-Boutigue

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

  1. Serum Catestatin Level as a Novel Biomarker of Oral Lichen Planus.Medical sciences (Basel, Switzerland) · 2026
    Article
  2. The role of chromogranin A cleavage products in onset of type 1 and 2 diabetes.Frontiers in clinical diabetes and healthcare · 2026
    Review
  3. Review
  4. Review
  5. Serum Catestatin Level as a Stratification Assessment Tool in Non-Critical COVID-19 Patients.International journal of environmental research and public health · 2023
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Francesco ScavelloBioMaterials and BioEngeneering, Institut National de la Santé et de la Recherche Médicale UMR_S 1121, Federation of Translational Medicine Faculty, of Odontology, University of Strasbourg, Hôpital Civil, Porte de L'Hôpital, 67000, Strasbourg, France.
Angela MutschlerBioMaterials and BioEngeneering, Institut National de la Santé et de la Recherche Médicale UMR_S 1121, Federation of Translational Medicine Faculty, of Odontology, University of Strasbourg, Hôpital Civil, Porte de L'Hôpital, 67000, Strasbourg, France.
Sophie HelléBioMaterials and BioEngeneering, Institut National de la Santé et de la Recherche Médicale UMR_S 1121, Federation of Translational Medicine Faculty, of Odontology, University of Strasbourg, Hôpital Civil, Porte de L'Hôpital, 67000, Strasbourg, France.
Francis SchneiderBioMaterials and BioEngeneering, Institut National de la Santé et de la Recherche Médicale UMR_S 1121, Federation of Translational Medicine Faculty, of Odontology, University of Strasbourg, Hôpital Civil, Porte de L'Hôpital, 67000, Strasbourg, France.
Sylvette Chasserot-GolazCentre National de la Recherche Scientifique, Institut des Neurosciences Cellulaires et Intégratives, University of Strasbourg, Strasbourg, France.
Jean-Marc StrubCentre National de la Recherche Scientifique, Laboratory of Bio-Organic Mass Spectrometry, Analytical Sciences Department, Pluridisciplinary Institute Hubert Curien, UMR 7178, University of Strasbourg, Strasbourg, France.
Sarah CianferaniCentre National de la Recherche Scientifique, Laboratory of Bio-Organic Mass Spectrometry, Analytical Sciences Department, Pluridisciplinary Institute Hubert Curien, UMR 7178, University of Strasbourg, Strasbourg, France.
Youssef HaikelBioMaterials and BioEngeneering, Institut National de la Santé et de la Recherche Médicale UMR_S 1121, Federation of Translational Medicine Faculty, of Odontology, University of Strasbourg, Hôpital Civil, Porte de L'Hôpital, 67000, Strasbourg, France.
Marie-Hélène Metz-BoutigueBioMaterials and BioEngeneering, Institut National de la Santé et de la Recherche Médicale UMR_S 1121, Federation of Translational Medicine Faculty, of Odontology, University of Strasbourg, Hôpital Civil, Porte de L'Hôpital, 67000, Strasbourg, France. marie-helene.metz@inserm.fr.
Inserm · FRUniversité de Strasbourg · FRInstitut Pluridisciplinaire Hubert Curien · FRInstitut des Neurosciences Cellulaires et Intégratives · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chromogranin A (CgA) is the precursor of several antimicrobial peptides, such as Catestatin (Cts, bovine CgA344-364), initially described as a potent inhibitor of catecholamines. This peptide displays direct antimicrobial activities and contributes to immune system regulation. The aim of the present study is to investigate a designed peptide based on Cts to fight infections against superbugs and more particularly Staphylococcus aureus. In addition to Cateslytin (Ctl, bovine CgA344-358), the active domain of Catestatin, several peptides including dimers, D-isomer and the new designed peptide DOPA-K-DOPA-K-DOPA-TLRGGE-RSMRLSFRARGYGFR (Dopa

Indexed as

Chromogranin AImmunity, InnatePeptide FragmentsStaphylococcus aureusAnimalsAnti-Bacterial AgentsAntimicrobial PeptidesCattleDendritic CellsHumansMacrophagesMicrobial Sensitivity TestsAnti-Bacterial AgentsAntimicrobial PeptidesChromogranin Achromogranin A (344-364)Peptide Fragments

Identifiers

PMID34341386
PMCPMC8329280
OpenAlexW3190689861

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.