Evidence map›Paper›PMID 34341249›Full record

ArticleSaudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association

Hassan Abdelnaby, Ndeye Coumba Ndiaye, Ferdinando D'Amico, Ahmed Mahmoud Fouad, Sameh Hassan, Alaa Elshafey, Wafaa Al Hashash, Mohammed Faisal, Yousef Alshamali, Talal Al-Taweel and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Cancers · 2025
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  5. Role and molecular mechanism of NOD2 in chronic non-communicable diseases.Journal of molecular medicine (Berlin, Germany) · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 4 countries.

Hassan AbdelnabyDepartment of Endemic and Infectious Diseases, Suez Canal University, Ismailia, Egypt; Department of Internal Medicine, Division of Gastroenterology, Al Sabah Hospital, Ministry of Health, Kuwait.
Ndeye Coumba NdiayeInserm U1256 « Nutrition - Genetics and Exposure to Environmental Risks - NGERE », University of Lorraine, Vandoeuvre-les-Nancy, France.
Ferdinando D'AmicoDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Ahmed Mahmoud FouadDepartment of Public Health, Occupational and Environmental Medicine, Ismailia, Italy.
Sameh HassanDepartment of Internal Medicine, Division of Gastroenterology, Al Sabah Hospital, Ministry of Health, Kuwait.
Alaa ElshafeyMedical Genetics, Pediatric Department, Menofia University, Egypt; Kuwait Medical Genetic Centre, Ministry of Health, Kuwait.
Wafaa Al HashashDepartment of Internal Medicine, Division of Gastroenterology, Al Sabah Hospital, Ministry of Health, Kuwait.
Mohammed FaisalSurgical Oncology Unit, Department of Surgery, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Yousef AlshamaliDepartment of Internal Medicine, Division of Gastroenterology, Jaber Al-Ahmad Hospital, Ministry of Health, Kuwait.
Talal Al-TaweelDepartment of Internal Medicine, Division of Gastroenterology, Jaber Al-Ahmad Hospital, Ministry of Health, Kuwait.
Laurent Peyrin-BirouletInserm U1256 « Nutrition - Genetics and Exposure to Environmental Risks - NGERE », University of Lorraine, Vandoeuvre-les-Nancy; InsermU954, Department of Gastroenterology, Nancy University Hospital, University of Lorraine, Vandoeuvre Les Nancy, France.
Ministry of Health · KWInserm · FRSuez Canal University · EGHumanitas University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Nucleotide-binding oligomerization domain-containing two (NOD2/CARD15) gene polymorphisms are implicated in the pathogenesis of Crohn's disease (CD). Aim: To describe the allelic frequency of NOD2/CARD15 gene variants among Kuwaiti patients with CD and investigate potential genotype/phenotype associations. Methods: Adult Kuwaiti citizens with an established diagnosis of CD and healthy controls were enrolled from October 2018 to May 2020. Three common NOD2/CARD15 polymorphisms (R702W, G908R, and L1007fs) and P268S and IVS8 Results: Ninety adult Kuwaiti patients with CD and 210 healthy subjects (as controls) were recruited. P268S, IVS8 Conclusion: NOD2/CARD15 gene polymorphisms were significantly associated with an increased risk of disease and aggressive phenotypes among the Kuwaiti CD population.

Indexed as

Crohn DiseaseCase-Control StudiesGenetic Predisposition to DiseaseGenotypeHumansMutationNod2 Signaling Adaptor ProteinPhenotypePolymorphism, GeneticNOD2 protein, humanNod2 Signaling Adaptor ProteinCrohn'sKuwaitNOD2/CARD15polymorphisms

Identifiers

PMID34341249
PMCPMC8448012
OpenAlexW3191385201

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.