ArticleJournal of neurology, neurosurgery, and psychiatry2021
Longitudinal changes of spinal cord grey and white matter following spinal cord injury.
Article in Journal of neurology, neurosurgery, and psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
- Cervical Atrophy Following Complete Thoracic Spinal Cord Injury: Insights From a Multinational Cohort.European journal of neurology · 2026Article
- Pulsatile intraspinal pressure drives post-traumatic syringomyelia: evidence supporting the CSF pulsatile pressure dynamic equilibrium hypothesis.Fluids and barriers of the CNS · 2026Article
- Evolution of MRI Parameters from the Subacute to Chronic Phase After Human Traumatic Cervical Spinal Cord Injury: a Prospective, Observational Study. Part 2: Diffusion Tensor Imaging Characteristics.Clinical neuroradiology · 2026Observational
- Mechanical Remodeling and Mechanosensing after Spinal Cord Injury: From Molecular to Translational Approaches.Research (Washington, D.C.) · 2026Review
- Brain functional reorganization in pediatric patients with spinal cord injury and the impact of motor imagery training on it: a preliminary study.IBRO neuroscience reports · 2025Article
- Metabolic and Structural Alterations in the Motor System Following Spinal Cord Injury: An In-VivoJournal of neuroscience research · 2025Article
- Convective forces contribute to post-traumatic degeneration after spinal cord injury.Bioengineering & translational medicine · 2025Article
- Remote neurodegeneration in the lumbosacral cord one month after spinal cord injury: a cross-sectional MRI study.Annals of clinical and translational neurology · 2025Article
- Disability trajectories individuals with spinal cord injury in mainland China: do psychosocial resources and diseases factors predict trajectories?Spinal cord · 2025Observational
- Neurorehabilitation and white matter repair in traumatic spinal cord injury: a dialogue between clinical and preclinical studies.Frontiers in neurology · 2025Review
- Progressive Remote Axonal Degeneration Following Spinal Cord Injury: A Histological and MRI Study.Neurotrauma reports · 2025Article
- Clinical Assessment and Management of Acute Spinal Cord Injury.Journal of clinical medicine · 2024Review
- The relationship between the structural changes in the cervical spinal cord and sensorimotor function of children with thoracolumbar spinal cord injury (TLSCI).Spinal cord · 2024Article
- Longitudinal motor system changes from acute to chronic spinal cord injury.European journal of neurology · 2024Article
- Effects of tail nerve electrical stimulation on the activation and plasticity of the lumbar locomotor circuits and the prevention of skeletal muscle atrophy after spinal cord transection in rats.CNS neuroscience & therapeutics · 2024Article
- ACID: A comprehensive toolbox for image processing and modeling of brain, spinal cord, and ex vivo diffusion MRI data.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Article
- Single-cell analysis reveals region-heterogeneous responses in rhesus monkey spinal cord with complete injury.Nature communications · 2023Article
- A comprehensive look at the psychoneuroimmunoendocrinology of spinal cord injury and its progression: mechanisms and clinical opportunities.Military Medical Research · 2023Review
- Changes in respiratory structure and function after traumatic cervical spinal cord injury: observations from spinal cord and brain.Frontiers in neurology · 2023Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
objectivesTraumatic and non-traumatic spinal cord injury produce neurodegeneration across the entire neuraxis. However, the spatiotemporal dynamics of spinal cord grey and white matter neurodegeneration above and below the injury is understudied.
methodsWe acquired longitudinal data from 13 traumatic and 3 non-traumatic spinal cord injury patients (8-8 cervical and thoracic cord injuries) within 1.5 years after injury and 10 healthy controls over the same period. The protocol encompassed structural and diffusion-weighted MRI rostral (C2/C3) and caudal (lumbar enlargement) to the injury level to track tissue-specific neurodegeneration. Regression models assessed group differences in the temporal evolution of tissue-specific changes and associations with clinical outcomes.
resultsAt 2 months post-injury, white matter area was decreased by 8.5% and grey matter by 15.9% in the lumbar enlargement, while at C2/C3 only white matter was decreased (-9.7%). Patients had decreased cervical fractional anisotropy (FA: -11.3%) and increased radial diffusivity (+20.5%) in the dorsal column, while FA was lower in the lateral (-10.3%) and ventral columns (-9.7%) of the lumbar enlargement. White matter decreased by 0.34% and 0.35% per month at C2/C3 and lumbar enlargement, respectively, and grey matter decreased at C2/C3 by 0.70% per month.
conclusionsThis study describes the spatiotemporal dynamics of tissue-specific spinal cord neurodegeneration above and below a spinal cord injury. While above the injury, grey matter atrophy lagged initially behind white matter neurodegeneration, in the lumbar enlargement these processes progressed in parallel. Tracking trajectories of tissue-specific neurodegeneration provides valuable assessment tools for monitoring recovery and treatment effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.