Evidence map›Paper›PMID 34341118›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Disparate regulation of IMD signaling drives sex differences in infection pathology in

Crystal M Vincent, Marc S Dionne

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
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  13. Frontiers in microbiology · 2024
    Review
  14. bioRxiv : the preprint server for biology · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. Pre-copulatory reproductive behaviours are preserved inProceedings. Biological sciences · 2022
    Article
  19. Article
  20. Why do insects evolve immune priming? A search for crossroads.Developmental and comparative immunology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Crystal M VincentMRC Centre for Molecular Bacteriology and Infection, Imperial College London, London SW7 2AZ, United Kingdom; crystal.vincent@imperial.ac.uk m.dionne@imperial.ac.uk.ORCID 0000-0002-4812-4913
Marc S DionneMRC Centre for Molecular Bacteriology and Infection, Imperial College London, London SW7 2AZ, United Kingdom; crystal.vincent@imperial.ac.uk m.dionne@imperial.ac.uk.ORCID 0000-0002-8283-1750
Imperial College London · GB

Funding

Resource Project CoreU41HG000739 · NHGRI · HARVARD UNIVERSITY · PI PERRIMON, NORBERT · 2014 to 2022
$32.3M
Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Medical Research Council MR/N030117/1Medical Research Council MR/R00997X/1NHGRI NIH HHS U41 HG000739NIH HHS P40 OD018537Wellcome TrustWellcome Trust 207467/Z/17/Z
6 · The paper itself

Abstract

Male and female animals exhibit differences in infection outcomes. One possible source of sexually dimorphic immunity is the sex-specific costs of immune activity or pathology, but little is known about the independent effects of immune- versus microbe-induced pathology and whether these may differ for the sexes. Here, by measuring metabolic and physiological outputs in

Indexed as

AnimalsCarrier ProteinsDrosophila melanogasterDrosophila ProteinsEscherichia coli InfectionsFemaleGene Expression RegulationImmunity, InnateMaleMutationNuclear ProteinsRepressor ProteinsSex FactorsSignal TransductionTriglyceridesCarrier ProteinsDrosophila ProteinsNuclear Proteinspeptidoglycan recognition proteinRepressor ProteinsRYBP protein, DrosophilaTra protein, DrosophilaTriglyceridesDrosophila melanogasterIMDinfectionPGRP-LBsexual dimorphism

Identifiers

PMID34341118
PMCPMC8364183
OpenAlexW3190415676

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.