ArticleProceedings of the National Academy of Sciences of the United States of America2021
Robust surface-to-mass coupling and turgor-dependent cell width determine bacterial dry-mass density.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 87 citations in OpenAlex.
- Enzyme kinetics shapes the growth response of metabolic networks.PLoS computational biology · 2026Article
- Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy.FEBS letters · 2026Article
- A coma pattern-based autofocusing method resolves bacterial cold shock response at single-cell level.eLife · 2026Article
- Inferring bacterial cell size dynamics across media conditions.Scientific reports · 2026Article
- Multiparametric quantification of bacterial cells using digital holographic microscopy.Scientific reports · 2025Article
- High-throughput single-cell density measurements enable dynamic profiling of immune cell and drug response from patient samples.Nature biomedical engineering · 2025Article
- Bacterial cell widening alters periplasmic size and activates envelope stress responses.The EMBO journal · 2025Article
- Gene expression cycles drive non-exponential bacterial growth.Physical review research · 2025Article
- Cell Geometry Limits Bacterial Metabolic Efficiency.bioRxiv : the preprint server for biology · 2025Article
- Cell Geometry and Membrane Protein Crowding Constrain Growth Rate, Overflow Metabolism, Respiration, and Maintenance Energy.bioRxiv : the preprint server for biology · 2025Article
- Risk-reward trade-off during carbon starvation generates dichotomy in motility endurance among marine bacteria.Nature microbiology · 2025Article
- Are cell length and volume interchangeable in cell cycle analysis?Biophysical journal · 2025Article
- Plasma membrane folding enables constant surface area-to-volume ratio in growing mammalian cells.Current biology : CB · 2025Article
- Incoherent feedback from coupled amino acids and ribosome pools generates damped oscillations in growing E. coli.Nature communications · 2025Article
- Liposome-EncapsulatedACS synthetic biology · 2025Article
- Plasma membrane folding enables constant surface area-to-volume ratio in growing mammalian cells.bioRxiv : the preprint server for biology · 2025Article
- Single-cell data reveal heterogeneity of investment in ribosomes across a bacterial population.Nature communications · 2025Article
- Macromolecular Crowding in Cell Stress and Death.Sub-cellular biochemistry · 2025Review
- Compaction and Segregation of DNA inLife (Basel, Switzerland) · 2024Review
- Contribution of different macromolecules to the diffusion of a 40 nm particle in Escherichia coli.Biophysical journal · 2024Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During growth, cells must expand their cell volumes in coordination with biomass to control the level of cytoplasmic macromolecular crowding. Dry-mass density, the average ratio of dry mass to volume, is roughly constant between different nutrient conditions in bacteria, but it remains unknown whether cells maintain dry-mass density constant at the single-cell level and during nonsteady conditions. Furthermore, the regulation of dry-mass density is fundamentally not understood in any organism. Using quantitative phase microscopy and an advanced image-analysis pipeline, we measured absolute single-cell mass and shape of the model organisms
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