Evidence map›Paper›PMID 34341104›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Molecular basis for lipid recognition by the prostaglandin D

Heng Liu, R N V Krishna Deepak, Anna Shiriaeva, Cornelius Gati, Alexander Batyuk, Hao Hu, Uwe Weierstall, Wei Liu, Lei Wang, Vadim Cherezov and 2 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 16 citations in OpenAlex.

  1. Unique/Rapid Feedback Mechanisms of PGDBioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Molecular basis of lipid and ligand regulation of prostaglandin receptor DP2.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. G Protein-Coupled Receptor-Ligand Pose and Functional Class Prediction.International journal of molecular sciences · 2024
    Article
  9. Review
  10. Evaluation ofMolecules (Basel, Switzerland) · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Serial femtosecond crystallography.Nature reviews. Methods primers · 2022
    Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Heng LiuDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.
R N V Krishna DeepakBioinformatics Institute, Agency for Science, Technology and Research, Matrix 138671, Singapore.ORCID 0000-0001-6629-8450
Anna ShiriaevaBridge Institute, University of Southern California Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA 90089.ORCID 0000-0002-4082-7884
Cornelius GatiBridge Institute, University of Southern California Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA 90089.
Alexander BatyukLinac Coherent Light Source, Stanford Linear Accelerator Center National Accelerator Laboratory, Menlo Park, CA 94025.ORCID 0000-0002-9393-2880
Hao HuDepartment of Physics, Arizona State University, Tempe, AZ 85281.
Uwe WeierstallDepartment of Physics, Arizona State University, Tempe, AZ 85281.ORCID 0000-0002-3594-930X
Wei LiuCenter for Applied Structural Discovery at the Biodesign Institute, Arizona State University, Tempe, AZ 85281.
Lei WangDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.ORCID 0000-0002-3024-8627
Vadim CherezovBridge Institute, University of Southern California Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA 90089; chengzh@pitt.edu fanh@bii.a-star.edu.sg cherezov@usc.edu.ORCID 0000-0002-5265-3914
Hao FanBioinformatics Institute, Agency for Science, Technology and Research, Matrix 138671, Singapore; chengzh@pitt.edu fanh@bii.a-star.edu.sg cherezov@usc.edu.
Cheng ZhangDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261; chengzh@pitt.edu fanh@bii.a-star.edu.sg cherezov@usc.edu.ORCID 0000-0001-9042-4007
Arizona State University · USUniversity of Pittsburgh · USUniversity of Southern California · USAgency for Science, Technology and Research · SGFermi National Accelerator Laboratory · US

Funding

Structure, pharmacology and signaling of G protein-coupled receptors (GPCRs) in inflammationR35GM128641 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHENG ZHANG · 2018 to 2026
$3.5M
NIGMS NIH HHS R35 GM128641
6 · The paper itself

Abstract

Prostaglandin D

Indexed as

Crystallography, X-RayHumansLipid MetabolismMolecular Dynamics SimulationMutationProstaglandin D2Protein ConformationReceptors, ImmunologicReceptors, ProstaglandinProstaglandin D2prostaglandin D2 receptorReceptors, ImmunologicReceptors, ProstaglandinCRTH2 (DP2)crystal structurelipid bindingMD simulationsprostaglandin D2

Identifiers

PMID34341104
PMCPMC8364189
OpenAlexW3192701263

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.