Evidence map›Paper›PMID 34341094›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2021

A New England COVID-19 Registry of Patients With CNS Demyelinating Disease: A Pilot Analysis.

Kelli M Money, Ashmanie Mahatoo, Soleil Samaan, Pria Anand, Ursela Baber, Mary Bailey, Rohit Bakshi, Andrew Bouley, Aaron Bower, Jonathan Cahill and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology(R) neuroimmunology & neuroinflammation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Neurology(R) neuroimmunology & neuroinflammation · 2023
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 1 institution in 1 country.

Kelli M MoneyFrom the Department of Neurology (K.M.M., A.M., S.S., U.B., J.A.S.), Beth Israel Deaconess Medical Center, Boston; Department of Neurology (P.A.), Boston University School of Medicine, MA; The Mandell Comprehensive MS Center (M.B., P.W.), Hartford, CT; Department of Neurology (R.B., M.H.), Brigham and Women's Hospital, Boston; The Elliot Lewis Center (A. Bouley, J.K., E. Lathi), Wellesley, MA; Department of Neurology (A. Bower, E. Levit, E.E.L.), Yale School of Medicine, New Haven, CT; Department of Neurology (J.C.), Alpert Medical School of Brown University, Providence, RI; Department of Neurology (M.M.), Lahey Hospital, Burlington; Neurology Center of New England (S.N.), Foxboro, MA; and Department of Neurology (P.R.), Concord Hospital, Concord, NH.
Ashmanie MahatooFrom the Department of Neurology (K.M.M., A.M., S.S., U.B., J.A.S.), Beth Israel Deaconess Medical Center, Boston; Department of Neurology (P.A.), Boston University School of Medicine, MA; The Mandell Comprehensive MS Center (M.B., P.W.), Hartford, CT; Department of Neurology (R.B., M.H.), Brigham and Women's Hospital, Boston; The Elliot Lewis Center (A. Bouley, J.K., E. Lathi), Wellesley, MA; Department of Neurology (A. Bower, E. Levit, E.E.L.), Yale School of Medicine, New Haven, CT; Department of Neurology (J.C.), Alpert Medical School of Brown University, Providence, RI; Department of Neurology (M.M.), Lahey Hospital, Burlington; Neurology Center of New England (S.N.), Foxboro, MA; and Department of Neurology (P.R.), Concord Hospital, Concord, NH.
Soleil SamaanFrom the Department of Neurology (K.M.M., A.M., S.S., U.B., J.A.S.), Beth Israel Deaconess Medical Center, Boston; Department of Neurology (P.A.), Boston University School of Medicine, MA; The Mandell Comprehensive MS Center (M.B., P.W.), Hartford, CT; Department of Neurology (R.B., M.H.), Brigham and Women's Hospital, Boston; The Elliot Lewis Center (A. Bouley, J.K., E. Lathi), Wellesley, MA; Department of Neurology (A. Bower, E. Levit, E.E.L.), Yale School of Medicine, New Haven, CT; Department of Neurology (J.C.), Alpert Medical School of Brown University, Providence, RI; Department of Neurology (M.M.), Lahey Hospital, Burlington; Neurology Center of New England (S.N.), Foxboro, MA; and Department of Neurology (P.R.), Concord Hospital, Concord, NH.
Pria AnandFrom the Department of Neurology (K.M.M., A.M., S.S., U.B., J.A.S.), Beth Israel Deaconess Medical Center, Boston; Department of Neurology (P.A.), Boston University School of Medicine, MA; The Mandell Comprehensive MS Center (M.B., P.W.), Hartford, CT; Department of Neurology (R.B., M.H.), Brigham and Women's Hospital, Boston; The Elliot Lewis Center (A. Bouley, J.K., E. Lathi), Wellesley, MA; Department of Neurology (A. Bower, E. Levit, E.E.L.), Yale School of Medicine, New Haven, CT; Department of Neurology (J.C.), Alpert Medical School of Brown University, Providence, RI; Department of Neurology (M.M.), Lahey Hospital, Burlington; Neurology Center of New England (S.N.), Foxboro, MA; and Department of Neurology (P.R.), Concord Hospital, Concord, NH.ORCID 0000-0002-7421-7750
Ursela BaberFrom the Department of Neurology (K.M.M., A.M., S.S., U.B., J.A.S.), Beth Israel Deaconess Medical Center, Boston; Department of Neurology (P.A.), Boston University School of Medicine, MA; The Mandell Comprehensive MS Center (M.B., P.W.), Hartford, CT; Department of Neurology (R.B., M.H.), Brigham and Women's Hospital, Boston; The Elliot Lewis Center (A. Bouley, J.K., E. Lathi), Wellesley, MA; Department of Neurology (A. Bower, E. Levit, E.E.L.), Yale School of Medicine, New Haven, CT; Department of Neurology (J.C.), Alpert Medical School of Brown University, Providence, RI; Department of Neurology (M.M.), Lahey Hospital, Burlington; Neurology Center of New England (S.N.), Foxboro, MA; and Department of Neurology (P.R.), Concord Hospital, Concord, NH.
Mary BaileyFrom the Department of Neurology (K.M.M., A.M., S.S., U.B., J.A.S.), Beth Israel Deaconess Medical Center, Boston; Department of Neurology (P.A.), Boston University School of Medicine, MA; The Mandell Comprehensive MS Center (M.B., P.W.), Hartford, CT; Department of Neurology (R.B., M.H.), Brigham and Women's Hospital, Boston; The Elliot Lewis Center (A. Bouley, J.K., E. Lathi), Wellesley, MA; Department of Neurology (A. Bower, E. Levit, E.E.L.), Yale School of Medicine, New Haven, CT; Department of Neurology (J.C.), Alpert Medical School of Brown University, Providence, RI; Department of Neurology (M.M.), Lahey Hospital, Burlington; Neurology Center of New England (S.N.), Foxboro, MA; and Department of Neurology (P.R.), Concord Hospital, Concord, NH.
Rohit BakshiFrom the Department of Neurology (K.M.M., A.M., S.S., U.B., J.A.S.), Beth Israel Deaconess Medical Center, Boston; Department of Neurology (P.A.), Boston University School of Medicine, MA; The Mandell Comprehensive MS Center (M.B., P.W.), Hartford, CT; Department of Neurology (R.B., M.H.), Brigham and Women's Hospital, Boston; The Elliot Lewis Center (A. Bouley, J.K., E. Lathi), Wellesley, MA; Department of Neurology (A. Bower, E. Levit, E.E.L.), Yale School of Medicine, New Haven, CT; Department of Neurology (J.C.), Alpert Medical School of Brown University, Providence, RI; Department of Neurology (M.M.), Lahey Hospital, Burlington; Neurology Center of New England (S.N.), Foxboro, MA; and Department of Neurology (P.R.), Concord Hospital, Concord, NH.ORCID 0000-0001-8601-5534
Andrew BouleyFrom the Department of Neurology (K.M.M., A.M., S.S., U.B., J.A.S.), Beth Israel Deaconess Medical Center, Boston; Department of Neurology (P.A.), Boston University School of Medicine, MA; The Mandell Comprehensive MS Center (M.B., P.W.), Hartford, CT; Department of Neurology (R.B., M.H.), Brigham and Women's Hospital, Boston; The Elliot Lewis Center (A. Bouley, J.K., E. Lathi), Wellesley, MA; Department of Neurology (A. Bower, E. Levit, E.E.L.), Yale School of Medicine, New Haven, CT; Department of Neurology (J.C.), Alpert Medical School of Brown University, Providence, RI; Department of Neurology (M.M.), Lahey Hospital, Burlington; Neurology Center of New England (S.N.), Foxboro, MA; and Department of Neurology (P.R.), Concord Hospital, Concord, NH.ORCID 0000-0002-9077-2121
Aaron BowerFrom the Department of Neurology (K.M.M., A.M., S.S., U.B., J.A.S.), Beth Israel Deaconess Medical Center, Boston; Department of Neurology (P.A.), Boston University School of Medicine, MA; The Mandell Comprehensive MS Center (M.B., P.W.), Hartford, CT; Department of Neurology (R.B., M.H.), Brigham and Women's Hospital, Boston; The Elliot Lewis Center (A. Bouley, J.K., E. Lathi), Wellesley, MA; Department of Neurology (A. Bower, E. Levit, E.E.L.), Yale School of Medicine, New Haven, CT; Department of Neurology (J.C.), Alpert Medical School of Brown University, Providence, RI; Department of Neurology (M.M.), Lahey Hospital, Burlington; Neurology Center of New England (S.N.), Foxboro, MA; and Department of Neurology (P.R.), Concord Hospital, Concord, NH.
Jonathan CahillFrom the Department of Neurology (K.M.M., A.M., S.S., U.B., J.A.S.), Beth Israel Deaconess Medical Center, Boston; Department of Neurology (P.A.), Boston University School of Medicine, MA; The Mandell Comprehensive MS Center (M.B., P.W.), Hartford, CT; Department of Neurology (R.B., M.H.), Brigham and Women's Hospital, Boston; The Elliot Lewis Center (A. Bouley, J.K., E. Lathi), Wellesley, MA; Department of Neurology (A. Bower, E. Levit, E.E.L.), Yale School of Medicine, New Haven, CT; Department of Neurology (J.C.), Alpert Medical School of Brown University, Providence, RI; Department of Neurology (M.M.), Lahey Hospital, Burlington; Neurology Center of New England (S.N.), Foxboro, MA; and Department of Neurology (P.R.), Concord Hospital, Concord, NH.
Maria HoutchensFrom the Department of Neurology (K.M.M., A.M., S.S., U.B., J.A.S.), Beth Israel Deaconess Medical Center, Boston; Department of Neurology (P.A.), Boston University School of Medicine, MA; The Mandell Comprehensive MS Center (M.B., P.W.), Hartford, CT; Department of Neurology (R.B., M.H.), Brigham and Women's Hospital, Boston; The Elliot Lewis Center (A. Bouley, J.K., E. Lathi), Wellesley, MA; Department of Neurology (A. Bower, E. Levit, E.E.L.), Yale School of Medicine, New Haven, CT; Department of Neurology (J.C.), Alpert Medical School of Brown University, Providence, RI; Department of Neurology (M.M.), Lahey Hospital, Burlington; Neurology Center of New England (S.N.), Foxboro, MA; and Department of Neurology (P.R.), Concord Hospital, Concord, NH.ORCID 0000-0001-6077-0654
Joshua KatzFrom the Department of Neurology (K.M.M., A.M., S.S., U.B., J.A.S.), Beth Israel Deaconess Medical Center, Boston; Department of Neurology (P.A.), Boston University School of Medicine, MA; The Mandell Comprehensive MS Center (M.B., P.W.), Hartford, CT; Department of Neurology (R.B., M.H.), Brigham and Women's Hospital, Boston; The Elliot Lewis Center (A. Bouley, J.K., E. Lathi), Wellesley, MA; Department of Neurology (A. Bower, E. Levit, E.E.L.), Yale School of Medicine, New Haven, CT; Department of Neurology (J.C.), Alpert Medical School of Brown University, Providence, RI; Department of Neurology (M.M.), Lahey Hospital, Burlington; Neurology Center of New England (S.N.), Foxboro, MA; and Department of Neurology (P.R.), Concord Hospital, Concord, NH.
Ellen LathiFrom the Department of Neurology (K.M.M., A.M., S.S., U.B., J.A.S.), Beth Israel Deaconess Medical Center, Boston; Department of Neurology (P.A.), Boston University School of Medicine, MA; The Mandell Comprehensive MS Center (M.B., P.W.), Hartford, CT; Department of Neurology (R.B., M.H.), Brigham and Women's Hospital, Boston; The Elliot Lewis Center (A. Bouley, J.K., E. Lathi), Wellesley, MA; Department of Neurology (A. Bower, E. Levit, E.E.L.), Yale School of Medicine, New Haven, CT; Department of Neurology (J.C.), Alpert Medical School of Brown University, Providence, RI; Department of Neurology (M.M.), Lahey Hospital, Burlington; Neurology Center of New England (S.N.), Foxboro, MA; and Department of Neurology (P.R.), Concord Hospital, Concord, NH.
Elle LevitFrom the Department of Neurology (K.M.M., A.M., S.S., U.B., J.A.S.), Beth Israel Deaconess Medical Center, Boston; Department of Neurology (P.A.), Boston University School of Medicine, MA; The Mandell Comprehensive MS Center (M.B., P.W.), Hartford, CT; Department of Neurology (R.B., M.H.), Brigham and Women's Hospital, Boston; The Elliot Lewis Center (A. Bouley, J.K., E. Lathi), Wellesley, MA; Department of Neurology (A. Bower, E. Levit, E.E.L.), Yale School of Medicine, New Haven, CT; Department of Neurology (J.C.), Alpert Medical School of Brown University, Providence, RI; Department of Neurology (M.M.), Lahey Hospital, Burlington; Neurology Center of New England (S.N.), Foxboro, MA; and Department of Neurology (P.R.), Concord Hospital, Concord, NH.
Erin E LongbrakeFrom the Department of Neurology (K.M.M., A.M., S.S., U.B., J.A.S.), Beth Israel Deaconess Medical Center, Boston; Department of Neurology (P.A.), Boston University School of Medicine, MA; The Mandell Comprehensive MS Center (M.B., P.W.), Hartford, CT; Department of Neurology (R.B., M.H.), Brigham and Women's Hospital, Boston; The Elliot Lewis Center (A. Bouley, J.K., E. Lathi), Wellesley, MA; Department of Neurology (A. Bower, E. Levit, E.E.L.), Yale School of Medicine, New Haven, CT; Department of Neurology (J.C.), Alpert Medical School of Brown University, Providence, RI; Department of Neurology (M.M.), Lahey Hospital, Burlington; Neurology Center of New England (S.N.), Foxboro, MA; and Department of Neurology (P.R.), Concord Hospital, Concord, NH.
Matthew McAdamsFrom the Department of Neurology (K.M.M., A.M., S.S., U.B., J.A.S.), Beth Israel Deaconess Medical Center, Boston; Department of Neurology (P.A.), Boston University School of Medicine, MA; The Mandell Comprehensive MS Center (M.B., P.W.), Hartford, CT; Department of Neurology (R.B., M.H.), Brigham and Women's Hospital, Boston; The Elliot Lewis Center (A. Bouley, J.K., E. Lathi), Wellesley, MA; Department of Neurology (A. Bower, E. Levit, E.E.L.), Yale School of Medicine, New Haven, CT; Department of Neurology (J.C.), Alpert Medical School of Brown University, Providence, RI; Department of Neurology (M.M.), Lahey Hospital, Burlington; Neurology Center of New England (S.N.), Foxboro, MA; and Department of Neurology (P.R.), Concord Hospital, Concord, NH.
Salvatore NapoliFrom the Department of Neurology (K.M.M., A.M., S.S., U.B., J.A.S.), Beth Israel Deaconess Medical Center, Boston; Department of Neurology (P.A.), Boston University School of Medicine, MA; The Mandell Comprehensive MS Center (M.B., P.W.), Hartford, CT; Department of Neurology (R.B., M.H.), Brigham and Women's Hospital, Boston; The Elliot Lewis Center (A. Bouley, J.K., E. Lathi), Wellesley, MA; Department of Neurology (A. Bower, E. Levit, E.E.L.), Yale School of Medicine, New Haven, CT; Department of Neurology (J.C.), Alpert Medical School of Brown University, Providence, RI; Department of Neurology (M.M.), Lahey Hospital, Burlington; Neurology Center of New England (S.N.), Foxboro, MA; and Department of Neurology (P.R.), Concord Hospital, Concord, NH.
Pooja RaibagkarFrom the Department of Neurology (K.M.M., A.M., S.S., U.B., J.A.S.), Beth Israel Deaconess Medical Center, Boston; Department of Neurology (P.A.), Boston University School of Medicine, MA; The Mandell Comprehensive MS Center (M.B., P.W.), Hartford, CT; Department of Neurology (R.B., M.H.), Brigham and Women's Hospital, Boston; The Elliot Lewis Center (A. Bouley, J.K., E. Lathi), Wellesley, MA; Department of Neurology (A. Bower, E. Levit, E.E.L.), Yale School of Medicine, New Haven, CT; Department of Neurology (J.C.), Alpert Medical School of Brown University, Providence, RI; Department of Neurology (M.M.), Lahey Hospital, Burlington; Neurology Center of New England (S.N.), Foxboro, MA; and Department of Neurology (P.R.), Concord Hospital, Concord, NH.
Peter WadeFrom the Department of Neurology (K.M.M., A.M., S.S., U.B., J.A.S.), Beth Israel Deaconess Medical Center, Boston; Department of Neurology (P.A.), Boston University School of Medicine, MA; The Mandell Comprehensive MS Center (M.B., P.W.), Hartford, CT; Department of Neurology (R.B., M.H.), Brigham and Women's Hospital, Boston; The Elliot Lewis Center (A. Bouley, J.K., E. Lathi), Wellesley, MA; Department of Neurology (A. Bower, E. Levit, E.E.L.), Yale School of Medicine, New Haven, CT; Department of Neurology (J.C.), Alpert Medical School of Brown University, Providence, RI; Department of Neurology (M.M.), Lahey Hospital, Burlington; Neurology Center of New England (S.N.), Foxboro, MA; and Department of Neurology (P.R.), Concord Hospital, Concord, NH.
Jacob A SloaneFrom the Department of Neurology (K.M.M., A.M., S.S., U.B., J.A.S.), Beth Israel Deaconess Medical Center, Boston; Department of Neurology (P.A.), Boston University School of Medicine, MA; The Mandell Comprehensive MS Center (M.B., P.W.), Hartford, CT; Department of Neurology (R.B., M.H.), Brigham and Women's Hospital, Boston; The Elliot Lewis Center (A. Bouley, J.K., E. Lathi), Wellesley, MA; Department of Neurology (A. Bower, E. Levit, E.E.L.), Yale School of Medicine, New Haven, CT; Department of Neurology (J.C.), Alpert Medical School of Brown University, Providence, RI; Department of Neurology (M.M.), Lahey Hospital, Burlington; Neurology Center of New England (S.N.), Foxboro, MA; and Department of Neurology (P.R.), Concord Hospital, Concord, NH. jsloane@bidmc.harvard.edu.ORCID 0000-0003-0028-3031
Boston University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Clinical and Epidemiology Research in Neurology (CERN) Training ProgramT32NS105583 · NINDS · YALE UNIVERSITY · PI LICHTMAN, JUDITH H, SPUDICH, SERENA S · 2019 to 2023
$1.1M
NCATS NIH HHS UL1 TR001863NINDS NIH HHS T32 NS105583
6 · The paper itself

Abstract

BACKGROUND AND

objectivesWe sought to define the risk of severe coronavirus disease 2019 (COVID-19) infection requiring hospitalization in patients with CNS demyelinating diseases such as MS and the factors that increase the risk for severe infection to guide decisions regarding patient care during the COVID-19 pandemic.

methodsA pilot cohort of 91 patients with confirmed or suspected COVID-19 infection from the Northeastern United States was analyzed to characterize patient risk factors and factors associated with an increased severity of COVID-19 infection. Univariate analysis of variance was performed using the Mann-Whitney

resultsOur cohort demonstrated a 27.5% hospitalization rate and a 4.4% case fatality rate. Performance on Timed 25-Foot Walk before COVID-19 infection, age, number of comorbidities, and presenting symptoms of nausea/vomiting and neurologic symptoms (e.g., paresthesia or weakness) were independent risk factors for hospitalization, whereas headache predicted a milder course without hospitalization. An absolute lymphocyte count was lower in hospitalized patients during COVID-19 infection. Use of disease-modifying therapy did not increase the risk of hospitalization but was associated with an increased need for respiratory support. DISCUSSION: The case fatality and hospitalization rates in our cohort were similar to those found in MS and general population COVID-19 cohorts within the region. Hospitalization was associated with increased disability, age, and comorbidities but not disease-modifying therapy use.

Indexed as

COVID-19Demyelinating Autoimmune Diseases, CNSAdultCohort StudiesComorbidityFemaleHospitalizationHumansImmunologic FactorsMaleMiddle AgedMortalityNew EnglandPilot ProjectsRegistriesRespiration, ArtificialImmunologic Factors

Identifiers

PMID34341094
PMCPMC8362350
OpenAlexW3189674311

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