Evidence map›Paper›PMID 34341072›Full record

ArticleCancer research2021

Unraveling Ewing Sarcoma Tumorigenesis Originating from Patient-Derived Mesenchymal Stem Cells.

Anna Sole, Sandrine Grossetête, Maxime Heintzé, Loelia Babin, Sakina Zaïdi, Patrick Revy, Benjamin Renouf, Anne De Cian, Carine Giovannangeli, Cécile Pierre-Eugène and 9 more

Open access · bronzeAbstract read
In one paragraph

Article in Cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Chromoplexy: A Pathway to Genomic Complexity and Cancer Development.International journal of molecular sciences · 2025
    Review
  10. Article
  11. Review
  12. Article
  13. Chromoplexy.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Identification of Novel/RareInternational journal of molecular sciences · 2024
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 4 countries.

Anna SoleLaboratory of Genome Dynamics in the Immune System, Institut Imagine, INSERM UMR1163, Équipe Labellisée La Ligue Nationale Contre Le Cancer, Université Paris-Saclay, Université de Paris, Paris, France.
Sandrine GrossetêteINSERM U830, Équipe Labellisée La Ligue Nationale Contre Le Cancer, Paris Sciences et Lettres University, SIREDO Oncology Centre, Institut Curie, Paris, France.
Maxime HeintzéLaboratory of Genome Dynamics in the Immune System, Institut Imagine, INSERM UMR1163, Équipe Labellisée La Ligue Nationale Contre Le Cancer, Université Paris-Saclay, Université de Paris, Paris, France.
Loelia BabinLaboratory of Genome Dynamics in the Immune System, Institut Imagine, INSERM UMR1163, Équipe Labellisée La Ligue Nationale Contre Le Cancer, Université Paris-Saclay, Université de Paris, Paris, France.
Sakina ZaïdiINSERM U830, Équipe Labellisée La Ligue Nationale Contre Le Cancer, Paris Sciences et Lettres University, SIREDO Oncology Centre, Institut Curie, Paris, France.
Patrick RevyLaboratory of Genome Dynamics in the Immune System, Institut Imagine, INSERM UMR1163, Équipe Labellisée La Ligue Nationale Contre Le Cancer, Université Paris-Saclay, Université de Paris, Paris, France.ORCID 0000-0003-0758-8022
Benjamin RenoufMuseum National d'Histoire Naturelle, Inserm U1154, CNRS UMR 7196, Sorbonne Universités, Paris, France.
Anne De CianMuseum National d'Histoire Naturelle, Inserm U1154, CNRS UMR 7196, Sorbonne Universités, Paris, France.
Carine GiovannangeliMuseum National d'Histoire Naturelle, Inserm U1154, CNRS UMR 7196, Sorbonne Universités, Paris, France.
Cécile Pierre-EugèneINSERM U830, Équipe Labellisée La Ligue Nationale Contre Le Cancer, Paris Sciences et Lettres University, SIREDO Oncology Centre, Institut Curie, Paris, France.
Isabelle Janoueix-LeroseyINSERM U830, Équipe Labellisée La Ligue Nationale Contre Le Cancer, Paris Sciences et Lettres University, SIREDO Oncology Centre, Institut Curie, Paris, France.
Lucile CouronnéLaboratory of Onco-Hematology, Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutical Implications, Institut Imagine, INSERM UMR1163, University of Paris, Paris, France.ORCID 0000-0002-1357-5482
Sophie KaltenbachLaboratory of Onco-Hematology, Institut Necker - Enfants Malades, Assistance Publique - Hôpitaux de Paris (APHP), Paris, France.
Mark TomishimaDevelopmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Maria JasinDevelopmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Thomas G P GrünewaldDivision of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Olivier DelattreINSERM U830, Équipe Labellisée La Ligue Nationale Contre Le Cancer, Paris Sciences et Lettres University, SIREDO Oncology Centre, Institut Curie, Paris, France.
Didier Surdez *INSERM U830, Équipe Labellisée La Ligue Nationale Contre Le Cancer, Paris Sciences et Lettres University, SIREDO Oncology Centre, Institut Curie, Paris, France. erika.brunet@inserm.fr didier.surdez@balgrist.ch.ORCID 0000-0002-7118-7859
Erika Brunet *Laboratory of Genome Dynamics in the Immune System, Institut Imagine, INSERM UMR1163, Équipe Labellisée La Ligue Nationale Contre Le Cancer, Université Paris-Saclay, Université de Paris, Paris, France. erika.brunet@inserm.fr didier.surdez@balgrist.ch.ORCID 0000-0002-1726-4673
Inserm · FRCentre National de la Recherche Scientifique · FRHôpital Necker-Enfants Malades · FRMemorial Sloan Kettering Cancer Center · USGerman Cancer Research Center · DE

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Homology-directed repair: BRCA2 and RAD51 paralogsR35CA253174 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Maria Jasin · 2020 to 2026
$6.7M
NCI NIH HHS P30 CA008748NCI NIH HHS R35 CA253174
6 · The paper itself

Abstract

Ewing sarcoma is characterized by pathognomonic translocations, most frequently fusing

Indexed as

Cell Transformation, NeoplasticDisease SusceptibilityAnimalsBiomarkersCells, CulturedComputational BiologyCRISPR-Cas SystemsDisease Models, AnimalGene EditingGene Expression ProfilingGene RearrangementGene TargetingHeterograftsHumansImmunophenotypingIn Situ Hybridization, FluorescenceBiomarkers

Identifiers

PMID34341072
PMCPMC8487988
OpenAlexW3188029091

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.