Evidence map›Paper›PMID 34341070›Full record

ArticleRNA (New York, N.Y.)2021

Impact of pseudouridylation, substrate fold, and degradosome organization on the endonuclease activity of RNase E.

Md Saiful Islam, Katarzyna J Bandyra, Yanjie Chao, Jörg Vogel, Ben F Luisi

Open access · hybridAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. In vitro cleavage requirements and specificities of mycobacterial RNase E.Biochemical and biophysical research communications · 2026
    Article
  3. Article
  4. Article
  5. Functions and therapeutic applications of pseudouridylation.Nature reviews. Molecular cell biology · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Md Saiful IslamDepartment of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom.
Katarzyna J BandyraDepartment of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom.
Yanjie ChaoRNA Biology Group, Institute of Molecular Infection Biology, University of Würzburg, D-97080 Würzburg, Germany.ORCID 0000-0002-5735-7954
Jörg VogelRNA Biology Group, Institute of Molecular Infection Biology, University of Würzburg, D-97080 Würzburg, Germany.
Ben F LuisiDepartment of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom.ORCID 0000-0003-1144-9877
University of Cambridge · GBChinese Academy of Sciences · CNUniversity of Würzburg · DE

Funding

Wellcome Trust 200873/Z/16/Z
6 · The paper itself

Abstract

The conserved endoribonuclease RNase E dominates the dynamic landscape of RNA metabolism and underpins control mediated by small regulatory RNAs in diverse bacterial species. We explored the enzyme's hydrolytic mechanism, allosteric activation, and interplay with partner proteins in the multicomponent RNA degradosome assembly of

Indexed as

Binding SitesEndoribonucleasesEscherichia coliEscherichia coli ProteinsMultienzyme ComplexesNucleic Acid ConformationPolyribonucleotide NucleotidyltransferaseProtein ConformationPseudouridineRNA, BacterialRNA HelicasesdegradosomeEndoribonucleasesEscherichia coli ProteinsMultienzyme ComplexesPolyribonucleotide NucleotidyltransferasePseudouridineribonuclease ERNA, BacterialRNA Helicasesmodified RNApseudouridineribonuclease mechanismriboregulationRNA degradosomeRNA recognition

Identifiers

PMID34341070
PMCPMC8522691
OpenAlexW3189770525

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.