ArticleBMJ global health2021
The genomic epidemiology of multi-drug resistant invasive non-typhoidal
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Article in BMJ global health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
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37citing papers in PubMed, 2 pooled it
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Antimicrobial resistance in community-acquired enteric pathogens among children aged ≤ 10-years in low-and middle-income countries: a systematic review and meta-analysis.Frontiers in microbiology · 2025Pooled it
- Complications and mortality of non-typhoidal salmonella invasive disease: a global systematic review and meta-analysis.The Lancet. Infectious diseases · 2022Pooled it
- Global genomic surveillance ofmBio · 2026Article
- Prevalence, serotype diversity, and antibiotic resistance of non-typhoidal Salmonella in East African poultry: A systematic review and meta-analysis.Poultry science · 2026Article
- Pan genome clustering identifies a novel mosaic prophage specific to Salmonella Enteritidis lineage associated with the invasive disease in India.PLoS neglected tropical diseases · 2026Article
- Article
- Need, demand, and feasibility for a new iNTS vaccine: stakeholder insights from eight African countries.NPJ vaccines · 2026Article
- Development of a GMMA-based candidate vaccine against invasive nontyphoidalFrontiers in immunology · 2026Article
- Epidemiology, resistance profiles, and molecular characteristics of pediatric salmonella isolates: prevalence of a clonalFrontiers in cellular and infection microbiology · 2026Article
- Leveraging Artificial Intelligence to Advance Bioinformatics in Africa: Opportunities, Challenges, and Ethical Considerations in Combating Antimicrobial Resistance.Bioinformatics and biology insights · 2026Article
- Genomic characterization of Salmonella enterica isolates causing typhoid among Ghanaian patients.PloS one · 2026Article
- Circulation of Salmonella spp. between humans, animals and the environment in animal-owning households in Malawi.Nature communications · 2025Article
- Rational design of a multi epitope vaccine against Salmonella typhi via subtractive proteomics, reverse vaccinology and molecular modeling.Scientific reports · 2025Article
- The Economic and Public Health Burden of Foodborne Illness in Somalia: Prevalence, Costs, and Policy Imperatives.Public health challenges · 2025Article
- Non-typhoidal Salmonella combination vaccines: clinical development plan and regulatory considerations.Vaccine · 2025Review
- Antibiotic susceptibility patterns ofMicrobiology spectrum · 2025Article
- Prevalence and antimicrobial resistance patterns of nontyphoidal Salmonella in Ghana: a systematic review and meta-analysis.Tropical medicine and health · 2025Review
- Article
- The global, regional, and national burden of Invasive Non-typhoidal Salmonella (iNTS): An analysis from the Global Burden of Disease Study 1990-2021.PLoS neglected tropical diseases · 2025Article
- MtlD as a therapeutic target for intestinal and systemic bacterial infections.Journal of bacteriology · 2025Article
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Authors and funding
53 authors at 19 institutions in 20 countries.
Se Eun Park *International Vaccine Institute, Seoul, Republic of Korea.ORCID 0000-0002-1632-3045
Duy Thanh Pham *The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
Gi Deok PakInternational Vaccine Institute, Seoul, Republic of Korea.
Ursula PanznerInternational Vaccine Institute, Seoul, Republic of Korea.
Ligia Maria Cruz EspinozaInternational Vaccine Institute, Seoul, Republic of Korea.
Vera von KalckreuthInternational Vaccine Institute, Seoul, Republic of Korea.
Justin ImInternational Vaccine Institute, Seoul, Republic of Korea.
Ondari D MogeniInternational Vaccine Institute, Seoul, Republic of Korea.
Heidi Schütt-GerowittInternational Vaccine Institute, Seoul, Republic of Korea.
John A CrumpCentre for International Health, University of Otago, Dunedin, New Zealand.ORCID 0000-0002-4529-102X
Robert F BreimanCenters for Disease Control and Prevention, KEMRI Complex, Nairobi, Kenya.
Yaw Adu-SarkodieKwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Ellis Owusu-DaboKwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Raphaël RakotozandrindrainyUniversity of Antananarivo, Antananarivo, Madagascar.
Abdramane Bassiahi SouraInstitut Supérieur des Sciences de la Population, University of Ouagadougou, Ouagadougou, Burkina Faso.
Abraham AseffaArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Nagla GasmelseedFaculty of Medicine, University of Gezira, Wad Medani, Sudan.
Arvinda SookaNational Institute for Communicable Diseases, Johannesburg, South Africa.
Karen H KeddySchool of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Jürgen MayBernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
Peter AabyBandim Health Project, Bissau, Guinea-Bissau.
Holly M BiggsDivision of Infectious Diseases and International Health, Duke University Medical Center, Durham, North Carolina, USA.
Julian T HertzDivision of Infectious Diseases and International Health, Duke University Medical Center, Durham, North Carolina, USA.
Joel M MontgomeryCenters for Disease Control and Prevention, KEMRI Complex, Nairobi, Kenya.
Leonard CosmasCenters for Disease Control and Prevention, KEMRI Complex, Nairobi, Kenya.
Beatrice OlackKenya Medical Research Institute, Nairobi, Kenya.
Barry FieldsCenters for Disease Control and Prevention, KEMRI Complex, Nairobi, Kenya.
Nimako SarpongKwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Tsiriniaina Jean Luco RazafindrabeUniversity of Antananarivo, Antananarivo, Madagascar.
Tiana Mirana RaminosoaUniversity of Antananarivo, Antananarivo, Madagascar.
Leon Parfait KaboreSchiphra Hospital, Ouagadougou, Burkina Faso.
Emmanuel SampoSchiphra Hospital, Ouagadougou, Burkina Faso.
Mekonnen TeferiArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Biruk YeshitelaArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Muna Ahmed El TayebFaculty of Medicine, University of Gezira, Wad Medani, Sudan.
Ralf KrumkampBernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
Denise Myriam DekkerBernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
Anna JaegerBernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
Adama TallInstitute Pasteur de Dakar, Dakar, Senegal.
Amy GassamaInstitute Pasteur de Dakar, Dakar, Senegal.
Aissatou NiangInstitute Pasteur de Dakar, Dakar, Senegal.
Morten Bjerregaard-AndersenBandim Health Project, Bissau, Guinea-Bissau.
Sandra Valborg LøfbergBandim Health Project, Bissau, Guinea-Bissau.
Jessica Fung DeerinInternational Vaccine Institute, Seoul, Republic of Korea.
Jin Kyung ParkInternational Vaccine Institute, Seoul, Republic of Korea.
Frank KoningsInternational Vaccine Institute, Seoul, Republic of Korea.
Megan E CareyDepartment of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK.
Sandra Van PuyveldeMedicine, Cambridge University, Cambridge, UK.
Mohammad AliInternational Vaccine Institute, Seoul, Republic of Korea.
John ClemensInternational Vaccine Institute, Seoul, Republic of Korea.
Gordon DouganDepartment of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK.
Stephen BakerDepartment of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK sgb47@medschl.cam.ac.uk.
Florian MarksInternational Vaccine Institute, Seoul, Republic of Korea.
International Vaccine Institute · KRGerman Center for Infection Research · DEKenya Medical Research Institute · KEArmauer Hansen Research Institute · ETInstitut Pasteur de Dakar · SNKwame Nkrumah University of Science and Technology · GHStatens Serum Institut · DKUniversity of Antananarivo · MGUniversity of Cambridge · GBDuke Medical Center · USDuke University · USEmory University · USNational Institute for Communicable DiseasesUniversité Joseph Ki-Zerbo · BFUniversity of Antwerp · BEUniversity of Gezira · SDUniversity of Hafr Al-Batin · SAUniversity of Oxford · GBUniversity of the Witwatersrand · ZA
Funding
Social and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI Nwora Lance Okeke · 2005 to 2026
$50.5MFogarty International Clinical Research Scholars Support Center @ Vanderbilt-AAMCR24TW007988 · FIC · VANDERBILT UNIVERSITY · PI VERMUND, STEN H. · 2007 to 2011
$27.6MViral and Host Determinants of HIV-1 TransmissionU01AI067854 · NIAID · DUKE UNIVERSITY · PI HAYNES, BARTON F · 2005 to 2005
$14.9MHIV/AIDS Clinical Trials UnitU01AI069484 · NIAID · DUKE UNIVERSITY · PI BARTLETT, JOHN A · 2007 to 2011
$14.6MInternational Clinical Trials UnitU01AI062563 · NIAID · DUKE UNIVERSITY · PI BARTLETT, JOHN A · 2004 to 2007
$4.0MThe Impact and Society Ecology of Bacterial Zoonoses in Northern Tanzania: UnderR01TW009237 · FIC · DUKE UNIVERSITY · PI CRUMP, JOHN ANDREW · 2011 to 2014
$1.7MBiotechnology and Biological Sciences Research Council BB/J010367FIC NIH HHS R01 TW009237FIC NIH HHS R24 TW007988NIAID NIH HHS P30 AI064518NIAID NIH HHS U01 AI062563NIAID NIH HHS U01 AI067854NIAID NIH HHS U01 AI069484Wellcome TrustWellcome Trust 215515/Z/19/Z
Abstract
backgroundInvasive non-typhoidal
methodsA total of 166 iNTS isolates collected from a multi-centre surveillance in 10 African countries (2010-2014) and a fever study in Ghana (2007-2009) were genome sequenced to investigate the geographical distribution, antimicrobial genetic determinants and population structure of iNTS serotypes-genotypes. Phylogenetic analyses were conducted in the context of the existing genomic frameworks for various iNTS serovars. Population-based incidence of MDR-iNTS disease was estimated in each study site.
results
conclusionsWe identified the circulation of multiple MDR iNTS serovar STs in the sampled sub-Saharan African countries. Investment in the development and deployment of iNTS vaccines coupled with intensified antimicrobial resistance surveillance are essential to limit the impact of these pathogens in Africa.
Indexed as
Pharmaceutical PreparationsSalmonella typhimuriumChildGenomicsHumansKenyaPhylogenyPharmaceutical Preparationscross-sectional surveyepidemiologymedical microbiologytyphoid and paratyphoid fevers
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