Evidence map›Paper›PMID 34340678›Full record

ArticleBMC cancer2021

Haplotype analysis on correlation between transcription factor 7-like 2 gene polymorphism and breast cancer risk.

Yang Wang, Xiaojuan Men, Yongxue Gu, Huidong Wang, Zhicai Xu

RetractedOpen access · goldAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yang WangDepartment of Galactophore Surgery, Weifang People's Hospital, No.151 Guangwen Street, Kuiwen District, Weifang, 261041, Shandong Province, People's Republic of China.
Xiaojuan MenDepartment of Galactophore Surgery, Weifang People's Hospital, No.151 Guangwen Street, Kuiwen District, Weifang, 261041, Shandong Province, People's Republic of China.
Yongxue GuDepartment of Galactophore Surgery, Weifang People's Hospital, No.151 Guangwen Street, Kuiwen District, Weifang, 261041, Shandong Province, People's Republic of China.
Huidong WangDepartment of Galactophore Surgery, Weifang People's Hospital, No.151 Guangwen Street, Kuiwen District, Weifang, 261041, Shandong Province, People's Republic of China.
Zhicai XuDepartment of Galactophore Surgery, Weifang People's Hospital, No.151 Guangwen Street, Kuiwen District, Weifang, 261041, Shandong Province, People's Republic of China. xuzhicai2268@163.com.
Weifang People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUp to now, limited researches focused on the association between transcription factor 7-like 2 gene (TF7L2) gene single nucleotide polymorphisms (SNPs) and breast cancer (BC) risk. The aim of this study was to evaluate the associations between TF7L2 and BC risk in Chinese Han population.

methodsLogistic regression model was used to test the correlation between polymorphisms and BC risk. Strength of association was evaluated by odds ratio (OR) and 95% confidence interval (CI). Generalized multifactor dimensionality reduction (GMDR) was applied to analyze the SNP-SNP and gene-environment interaction.

resultsLogistic regression analysis indicated that the BC risk was obviously higher in carriers of rs1225404 polymorphism C allele than that in TT genotype carriers (TC or CC versus TT), adjusted OR (95%CI) =1.40 (1.09-1.72). Additionally, we also discovered that people with rs7903146- T allele had an obviously higher risk of BC than people with CC allele (CT or TT versus CC), adjusted OR (95%CI) =1.44 (1.09-1.82). GMDR model was used to research the effect of interaction among 4 SNPs and environmental factors on BC risk. We discovered an important two-locus model (p = 0.0100) including rs1225404 and abdominal obesity, suggesting a potential gene-environment correlation between rs1225404 and abdominal obesity. In general, the cross-validation consistency of two-locus model was 10 of 10, and the testing accuracy was 0.632. Compared with subjects with normal waist circumference (WC) value and rs1225404 TT genotype, abdominal obese subjects with rs1225404 TC or CC genotype had the highest BC risk. After covariate adjustment, OR (95%CI) was 2.23 (1.62-2.89). Haplotype analysis indicated that haplotype containing rs1225404-T and rs7903146-C alleles were associated with higher BC risk.

conclusionsC allele of rs1225404 and T allele of rs7903146, interaction between rs1225404 and abdominal obesity, rs1225404-T and rs7903146-C haplotype were all related to increased BC risk.

Indexed as

Genetic Predisposition to DiseaseHaplotypesPolymorphism, Single NucleotideAdultAgedAllelesBreast NeoplasmsFemaleGene FrequencyGenetic Association StudiesGenotypeHumansMiddle AgedRiskTranscription Factor 7-Like 2 ProteinTranscription Factor 7-Like 2 ProteinBreast cancerHaplotypeInteractionPolymorphismsTranscription factor 7-like 2

Identifiers

PMID34340678
PMCPMC8327437
OpenAlexW3190060913

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.