Evidence map›Paper›PMID 34340660›Full record

ArticleBMC cardiovascular disorders2021

Baseline pro-inflammatory gene expression in whole blood is related to adverse long-term outcomes after transcatheter aortic valve replacement: a case control study.

Deena S Goldwater, Mei Leng, Arun Karlamangla, Teresa Seeman, David Elashoff, Jonathan M Wanagat, David B Reuben, Brian R Lindman, Steve Cole

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Deena S GoldwaterDivision of Cardiology, Department of Medicine, University of California, Los Angeles, CA, USA. dgoldwater@mednet.ucla.edu.ORCID 0000-0001-5722-9939
Mei LengDepartment of Biostatistics, University of California, Los Angeles, CA, USA.
Arun KarlamanglaDivision of Geriatrics, Department of Medicine, University of California, Los Angeles, CA, USA.
Teresa SeemanDivision of Geriatrics, Department of Medicine, University of California, Los Angeles, CA, USA.
David ElashoffDepartment of Biostatistics, University of California, Los Angeles, CA, USA.
Jonathan M WanagatDivision of Geriatrics, Department of Medicine, University of California, Los Angeles, CA, USA.
David B ReubenDivision of Geriatrics, Department of Medicine, University of California, Los Angeles, CA, USA.
Brian R LindmanStructural Heart and Valve Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Steve ColeSemel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
University of California, Los Angeles · USVanderbilt University Medical Center · US

Funding

USC/UCLA Center on Biodemography &Population HealthP30AG017265 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JENNIFER A AILSHIRE, HIRAM BELTRAN-SANCHEZ · 1999 to 2026
$17.9M
Inflammatory and immune system gene expression as a marker of vulnerability in older adult patients undergoing a cardiovascular procedureR03AG064319 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GOLDWATER, DEENA · 2019 to 2020
$140k
NIA NIH HHS P30 AG017265NIA NIH HHS R03 AG064319
6 · The paper itself

Abstract

backgroundAge-associated inflammation and immune system dysfunction have been implicated as mechanisms that increase risk for adverse long-term procedural outcomes in older adults. The purpose of this study was to investigate relationships between baseline inflammatory and innate antiviral gene expression and outcomes after transcatheter aortic valve replacement (TAVR) in older adults with severe aortic stenosis.

methodsWe performed a retrospective case-control study comparing pre-procedural pro-inflammatory and Type 1 interferon (IFN) gene expression in 48 controls with favorable outcomes (alive 1 year after TAVR with improved quality of life [QoL]) versus 48 individuals with unfavorable outcomes (dead by 1 year or alive at 1 year but with reduced QoL). Gene expression was evaluated in whole blood via (1) pre-defined composite scores of 19 inflammation-associated genes and 34 Type I IFN response genes, and (2) pro-inflammatory and antiviral transcription factor activity inferred from promotor based bioinformatics analyses of genes showing > 25% difference in average expression levels across groups. All analyses were adjusted for age, gender, body mass index, diabetes, immunosuppression, cardiovascular disease (CVD), and frailty.

resultsRelative to controls, those with unfavorable outcomes demonstrated higher expression of the pro-inflammatory gene composite prior to TAVR (p < 0.01) and bioinformatic indicators of elevated Nuclear Factor kB (p < 0.001) and Activator Protein 1 (p < 0.001) transcription factor activity, but no significant differences in Type I IFN-related gene expression.

conclusionsThese results demonstrate that a pro-inflammatory state prior to TAVR, independent of CVD severity and frailty status, is associated with worse long-term procedural outcomes.

Indexed as

AgedAged, 80 and overAortic Valve StenosisBiomarkersFemaleGene Expression RegulationHost-Pathogen InteractionsHumansImmunity, InnateInflammation MediatorsMaleRetrospective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsBiomarkersInflammation MediatorsGene expressionGeriatricsInflammationQuality of lifeTranscatheter aortic valve replacement

Identifiers

PMID34340660
PMCPMC8327421
OpenAlexW3191445894

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.