Evidence map›Paper›PMID 34340614›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2021

Tetrahydroquinazole-based secondary sulphonamides as carbonic anhydrase inhibitors: synthesis, biological evaluation against isoforms I, II, IV, and IX, and computational studies.

Emma Baglini, Rahul Ravichandran, Emanuela Berrino, Silvia Salerno, Elisabetta Barresi, Anna Maria Marini, Monica Viviano, Sabrina Castellano, Federico Da Settimo, Claudiu T Supuran and 2 more

Abstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Emma BagliniDepartment of Pharmacy, University of Pisa, Pisa, Italy.ORCID https://orcid.org/0000-0002-8378-4052
Rahul RavichandranDiSTABiF, University of Campania Luigi Vanvitelli, Caserta, Italy.ORCID https://orcid.org/0000-0002-1908-6161
Emanuela BerrinoNEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Sesto Fiorentino, Italy.ORCID https://orcid.org/0000-0002-4258-0678
Silvia SalernoDepartment of Pharmacy, University of Pisa, Pisa, Italy.ORCID https://orcid.org/0000-0002-6072-4698
Elisabetta BarresiDepartment of Pharmacy, University of Pisa, Pisa, Italy.ORCID https://orcid.org/0000-0002-9814-7195
Anna Maria MariniDepartment of Pharmacy, University of Pisa, Pisa, Italy.ORCID https://orcid.org/0000-0001-8664-375X
Monica VivianoDepartment of Pharmacy, Epigenetic Med Chem Lab, University of Salerno, Fisciano, Italy.ORCID https://orcid.org/0000-0003-1118-790X
Sabrina CastellanoDepartment of Pharmacy, Epigenetic Med Chem Lab, University of Salerno, Fisciano, Italy.
Federico Da SettimoDepartment of Pharmacy, University of Pisa, Pisa, Italy.ORCID https://orcid.org/0000-0002-7897-7917
Claudiu T SupuranNEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Sesto Fiorentino, Italy.ORCID https://orcid.org/0000-0003-4262-0323
Sandro CosconatiDiSTABiF, University of Campania Luigi Vanvitelli, Caserta, Italy.ORCID https://orcid.org/0000-0002-8900-0968
Sabrina TalianiDepartment of Pharmacy, University of Pisa, Pisa, Italy.ORCID https://orcid.org/0000-0001-8675-939X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A library of variously decorated

Indexed as

Carbon-13 Magnetic Resonance SpectroscopyCarbonic Anhydrase InhibitorsComputational BiologyDrug Evaluation, PreclinicalIsoenzymesMolecular Docking SimulationProton Magnetic Resonance SpectroscopyQuinazolinesStructure-Activity RelationshipSulfonamidesCarbonic Anhydrase InhibitorsIsoenzymesQuinazolinesSulfonamidesCarbonic anhydrases inhibitorssecondary sulphonamidesstructure–activity relationshipstetrahydroquinazole derivativestumour-related CA IX isoform

Identifiers

PMID34340614
PMCPMC8344263

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.