Evidence map›Paper›PMID 34340571›Full record

ArticleInnate immunity2021

Long non-coding RNA ZFAS1 alleviates sepsis-induced myocardial injury via target miR-34b-5p/SIRT1.

Dan-Dan Chen, Hong-Wu Wang, Xing-Jun Cai

Open access · goldAbstract read
In one paragraph

Article in Innate immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Review
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  6. Therapeutical progress in sepsis-induced cardiomyopathy.Frontiers in cardiovascular medicine · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Dan-Dan ChenDepartment of Critical Care Medicine, Haikou Hospital, Xiangya Medical College, Central South University, P.R. China.
Hong-Wu WangDepartment of Critical Care Medicine, Haikou Hospital, Xiangya Medical College, Central South University, P.R. China.
Xing-Jun CaiDepartment of Pulmonary and Critical Care Medicine, Hainan General Hospital, P.R. China.ORCID 0000-0001-8244-2416
Central South University · CNHainan General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long non-coding RNA ZFAS1 is down-regulated in sepsis. However, whether ZFAS1 participates in sepsis-induced cardiomyopathy (SIC) remains largely unknown. LPS injection to rats was used to establish an

Indexed as

AnimalsCell LineDisease Models, AnimalGene Expression RegulationHumansLipopolysaccharidesMaleMicroRNAsMyocardiumMyocytes, CardiacRatsRats, Sprague-DawleyRNA, Long NoncodingSepsisSirtuin 1LipopolysaccharidesMicroRNAsMIRN34 microRNA, ratRNA, Long NoncodingSirtuin 1ZFAS1 long non-coding RNA, humanlncRNA ZFAS1miR-34b-5psepsisSICSIRT1

Identifiers

PMID34340571
PMCPMC8419299
OpenAlexW3192087628

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.