Evidence map›Paper›PMID 34339750›Full record

ArticleNeuropharmacology2021

Different roles of T-type calcium channel isoforms in hypnosis induced by an endogenous neurosteroid epipregnanolone.

Ian Coulter, Tamara Timic Stamenic, Pierce Eggan, Brier R Fine, Timothy Corrigan, Douglas F Covey, Lingling Yang, Jen Q Pan, Slobodan M Todorovic

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. New directions in neurosteroid therapeutics in neuropsychiatry.Neuroscience and biobehavioral reviews · 2025
    Review
  3. 5β-Dihydrosteroids: Formation and Properties.International journal of molecular sciences · 2024
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Ian CoulterDepartment of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, 80045, USA.
Tamara Timic StamenicDepartment of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, 80045, USA.
Pierce EgganDepartment of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, 80045, USA.
Brier R FineDepartment of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, 80045, USA.
Timothy CorriganDepartment of Pediatrics, Division of Neurology, Translational Epilepsy Research Program, University of Colorado, Anschutz Medical Campus, Aurora, CO, 80045, USA.
Douglas F CoveyDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO, 63110, USA; Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Lingling YangStanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, USA.
Jen Q PanStanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, USA.
Slobodan M TodorovicDepartment of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, 80045, USA; Neuroscience and University of Colorado, Anschutz Medical Campus, Aurora, 80045, USA; Pharmacology Graduate Programs, University of Colorado, Anschutz Medical Campus, Aurora, 80045, USA. Electronic address: slobodan.todorovic@cuanschutz.edu.
University of Colorado Anschutz Medical Campus · USBroad Institute · USWashington University in St. Louis · US

Funding

ZEBRAFISH TRANSGENIC CORE - ROCKY MOUNTAIN NEUROLOGICAL DISORDERS CORE CENTERP30NS048154 · NINDS · UNIVERSITY OF COLORADO DENVER · PI RIBERA, ANGELES BADELL · 2004 to 2020
$10.1M
Voltage-gated calcium channels as target for anestheticsR35GM141802 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Slobodan M. Todorovic · 2021 to 2026
$3.1M
High-Throughput Screens for CaV3.3 Selective T-type Calcium Channel ModulatorsR01MH115045 · NIMH · BROAD INSTITUTE, INC. · PI COTTRELL, JEFFREY RICHARD, PAN, JEN QIAN · 2018 to 2020
$2.3M
Novel neurosteroid anesthetics and perioperative analgesiaR01GM123746 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI JEVTOVIC-TODOROVIC, VESNA · 2017 to 2025
$2.2M
In vivo imaging of thalamocortical excitability during anesthesiaR01GM102525 · NIGMS · UNIVERSITY OF VIRGINIA · PI TODOROVIC, SLOBODAN M. · 2014 to 2020
$2.0M
Potentiate Cav3.3 To Treat Cognitive Deficits Associated with Impaired Sleep SpindleR01MH131719 · NIMH · BROAD INSTITUTE, INC. · PI PAN, JEN QIAN, WEÏWER, MICHEL · 2022 to 2023
$1.8M
NIGMS NIH HHS R01 GM102525NIGMS NIH HHS R01 GM123746NIGMS NIH HHS R35 GM141802NIMH NIH HHS R01 MH115045NIMH NIH HHS R01 MH131719NINDS NIH HHS P30 NS048154
6 · The paper itself

Abstract

backgroundMany neuroactive steroids induce sedation/hypnosis by potentiating γ-aminobutyric acid (GABA

methodsHere, we utilized electroencephalographic (EEG) recordings to characterize thalamocortical oscillations, as well as behavioral assessment and mouse genetics with wild-type (WT) and different knockout (KO) models of T-channel isoforms to investigate potential sedative/hypnotic and immobilizing properties of EpiP.

resultsConsistent with increased oscillations in slower EEG frequencies, EpiP induced an hypnotic state in WT mice when injected alone intra-peritoneally (i.p.) and effectively facilitated anesthetic effects of isoflurane (ISO) and sevoflurane (SEVO). The Ca

conclusionWe posit that EpiP may have an important role as novel hypnotic and/or adjuvant to volatile anesthetic agents. We speculate that distinct hypnotic effects of EpiP across all three T-channel isoforms is due to their differential expression in thalamocortical circuitry.

Indexed as

Adjuvants, AnesthesiaAnesthetics, InhalationAnimalsBehavior, AnimalCalcium Channels, T-TypeElectroencephalographyHypnotics and SedativesIsofluraneIsomerismMaleMiceMice, Inbred C57BLMice, KnockoutPregnanoloneSevofluraneAdjuvants, AnesthesiaAnesthetics, InhalationCacna1g protein, mouseCacna1i protein, mouseCalcium Channels, T-TypeHypnotics and SedativesIsofluranePregnanoloneSevofluraneCalciumIsofluraneLow-voltage-activatedRighting reflexThalamusWithdrawal reflex

Identifiers

PMID34339750
PMCPMC8478885
OpenAlexW3192458807

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.