Evidence map›Paper›PMID 34339547›Full record

ArticleJournal of clinical pharmacy and therapeutics2022

Elevated INR in a COVID-19 patient after concomitant administration of favipiravir and warfarin: A case report.

Masao Sekimoto, Toru Imai, Shinji Hidaka, Nobutaka Chiba, Atsushi Sakurai, Mitsumasa Hata, Norikazu Kikuchi

Abstract readCase Reports
In one paragraph

Article in Journal of clinical pharmacy and therapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Masao SekimotoDepartment of Pharmacy, Nihon University Hospital, Tokyo, Japan.ORCID https://orcid.org/0000-0001-9895-6059
Toru ImaiDepartment of Pharmacy, Nihon University Itabashi Hospital, Tokyo, Japan.
Shinji HidakaDepartment of Pharmaceutical Regulatory Science, School of Pharmacy, Nihon University, Chiba, Japan.ORCID https://orcid.org/0000-0001-5605-4209
Nobutaka ChibaDivision of Emergency and Critical Care Medicine, Department of Acute Medicine, Nihon University School of Medicine, Tokyo, Japan.
Atsushi SakuraiDivision of Emergency and Critical Care Medicine, Department of Acute Medicine, Nihon University School of Medicine, Tokyo, Japan.
Mitsumasa HataDepartment of Cardiovascular Surgery, Nihon University Hospital, Tokyo, Japan.
Norikazu KikuchiDepartment of Pharmacy, Nihon University Hospital, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

WHAT IS KNOWN AND

objectiveFavipiravir is a promising treatment candidate for managing coronavirus disease 2019 (COVID-19). Warfarin has many drug interactions, but no interactions with favipiravir have been reported. CASE SUMMARY: Our patient was taking warfarin for deep vein thrombosis. The international normalized ratio (INR) was stable (1.65 to 2.0); however, it increased to 4.63 after administering favipiravir. The patient had no other factors justifying this change. WHAT IS NEW AND

conclusionFavipiravir and warfarin might have previously unidentified drug interactions that elevated the INR. Therefore, INR must be closely monitored when they are concomitantly administered in COVID-19 patients.

Indexed as

COVID-19 Drug TreatmentWarfarinAmidesAnticoagulantsDrug InteractionsHumansInternational Normalized RatioPyrazinesAmidesAnticoagulantsfavipiravirPyrazinesWarfarincoronavirus disease of 2019 (COVID-19)cytochrome P-450 (CYP)drug-drug interactions (DDIs)favipiravirinternational normalized ratio (INR)warfarin

Identifiers

PMID34339547
PMCPMC8447296

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.