Evidence map›Paper›PMID 34339476›Full record

ArticlePloS one2021

The risk of psoriasis in patients with uveitis: A nationwide population-based cohort study.

Yu-Yen Chen, Hsin-Hua Chen, Tzu-Chen Lo, Pesus Chou

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Yu-Yen ChenSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Hsin-Hua ChenSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Tzu-Chen LoSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Pesus ChouSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Chung Shan Medical University · TWNational Chung Hsing University · TWNational Yang Ming Chiao Tung University · TWTaichung Veterans General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate whether the risk of subsequent psoriasis and psoriatic arthritis development is increased in patients with uveitis.

methodsIn Taiwan's national health insurance research database, we identified 195,125 patients with new-onset uveitis between 2001 and 2013. We randomly selected 390,250 individuals without uveitis who were matched 2:1 to uveitis cases based on age, sex and year of enrolment. The characteristics of the two groups were compared. Using multivariate Cox regression, hazard ratios (HRs) for psoriasis or psoriatic arthritis corresponding to uveitis were computed after adjustment for age, sex, insurance cost and comorbidities. In subgroup analyses, separate HRs for mild psoriasis, severe psoriasis and psoriatic arthritis were calculated.

resultsThe mean age of the study cohort was 50.2 ± 17.2 years. Hypertension, diabetes, hyperlipidaemia and obesity were more prevalent in the uveitis group (all p < 0.0001). The hazard of psoriasis or psoriatic arthritis development was significantly greater in the uveitis group than in the non-uveitis group (p < 0.0001); this increased risk persisted after adjustment for confounders [adjusted HR = 1.41; 95% confidence interval (CI), 1.33-1.48]. Adjusted HRs showed an increasing trend from mild psoriasis (1.35; 95% CI, 1.28-1.44) to severe psoriasis (1.59; 95% CI, 1.30-1.94) and psoriatic arthritis (1.97; 95% CI, 1.60-2.42).

conclusionsThis nationwide population-based cohort study revealed that patients with uveitis have an increased risk of subsequent psoriasis or psoriatic arthritis development.

Indexed as

Severity of Illness IndexAdultComorbidityDatabases, FactualFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedPrognosisPsoriasisRetrospective StudiesRisk FactorsTaiwanUveitis

Identifiers

PMID34339476
PMCPMC8328291
OpenAlexW3192287829

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.