Evidence map›Paper›PMID 34339301›Full record

ArticleJournal of bacteriology2021

Structure-Function Characterization of Streptococcus intermedius Surface Antigen Pas.

Joshua L Mieher, Norbert Schormann, Ren Wu, Manisha Patel, Sangeetha Purushotham, Hui Wu, Jessica Scoffield, Champion Deivanayagam

Open access · greenAbstract read
In one paragraph

Article in Journal of bacteriology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. TargetingACS medicinal chemistry letters · 2026
    Article
  2. Article
  3. Future microbiology · 2025
    Review
  4. Review
  5. Article
  6. Recent Advances and Opportunities in the Study ofFrontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Joshua L MieherDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birminghamgrid.265892.2, Birmingham, Alabama, USA.
Norbert SchormannDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birminghamgrid.265892.2, Birmingham, Alabama, USA.
Ren WuDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birminghamgrid.265892.2, Birmingham, Alabama, USA.
Manisha PatelDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birminghamgrid.265892.2, Birmingham, Alabama, USA.
Sangeetha PurushothamDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birminghamgrid.265892.2, Birmingham, Alabama, USA.
Hui WuDepartment of Integrative Biomedical and Diagnostic Sciences, Oregon Health and Science University School of Dentistry, Portland, Oregon, USA.
Jessica ScoffieldDepartment of Microbiology, University of Alabama at Birminghamgrid.265892.2, Birmingham, Alabama, USA.
Champion DeivanayagamDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birminghamgrid.265892.2, Birmingham, Alabama, USA.
University of Alabama at Birmingham · USOregon Health & Science University · US

Funding

Dental Academic Research Training Program (DART)T90DE022736 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Amjad Javed · 2012 to 2026
$6.7M
Glycosylation & Function of an Oral Streptococcal AdhesinR01DE017954 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WU, HUI · 2007 to 2022
$5.8M
SMALL MOLECULE INHIBITORS OF CARIOGENIC BIOFILMSR01DE022350 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Christian Corey Melander, Hui Wu · 2012 to 2026
$4.3M
The Structural and Functional Determination of Streptococcus mutans AdherenceR01DE029007 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DEIVANAYAGAM, CHAMPION CHRISTDOSS SELVAKUMAR, WU, HUI · 2020 to 2024
$2.1M
PORT (Portland Oral health Research Training)R90DE031533 · NIDCR · OREGON HEALTH & SCIENCE UNIVERSITY · PI WU, HUI · 2021 to 2025
$821k
Inhibition of Streptococcus mutans by oral commensal streptococci and nitrie-mediated activityR00DE025913 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SCOFFIELD, JESSICA A · 2018 to 2020
$749k
Structural and Functional Studies on the Platelet Adherence Protein A of StreptocR21AI105038 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DEIVANAYAGAM, CHAMPION CHRISTDOSS SELVAKUMAR · 2014 to 2015
$404k
NIAID NIH HHS R21 AI105038NIDCR NIH HHS R00 DE025913NIDCR NIH HHS R00DE025913NIDCR NIH HHS R01 DE017954NIDCR NIH HHS R01DE017954NIDCR NIH HHS R01 DE022350NIDCR NIH HHS R01DE022350NIDCR NIH HHS R01 DE029007NIDCR NIH HHS R01DE029007NIDCR NIH HHS R90 DE031533NIDCR NIH HHS T90 DE022736NIDCR NIH HHS T-90DE022736-06
6 · The paper itself

Abstract

Streptococcus intermedius, an oral commensal bacterium, is found at various sites, including subgingival dental plaque, purulent infections, and cystic fibrosis lungs. Oral streptococci utilize proteins on their surface to adhere to tissues and/or surfaces localizing the bacteria, which subsequently leads to the development of biofilms, colonization, and infection. Among the 19 genomically annotated cell wall-attached surface proteins on S. intermedius, Pas is an adhesin that belongs to the antigen I/II (AgI/II) family. Here, we have structurally and functionally characterized Pas, particularly focusing on its microbial-host as well as microbial-microbial interactions. The crystal structures of V

Indexed as

Amino Acid SequenceAntigens, BacterialBacterial ProteinsCalciumGene Expression Regulation, BacterialModels, MolecularProtein BindingProtein ConformationPseudomonas aeruginosaStreptococcus intermediusAntigens, BacterialBacterial ProteinsCalciumCandida albicansprotein structure-functionStreptococcus intermediussurface antigens

Identifiers

PMID34339301
PMCPMC8477658
OpenAlexW3187908277

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.