Evidence map›Paper›PMID 34339273›Full record

ArticleAntimicrobial agents and chemotherapy2021

Associations between Varied Susceptibilities to PfATP4 Inhibitors and Genotypes in Ugandan Plasmodium falciparum Isolates.

Oriana Kreutzfeld, Stephanie A Rasmussen, Aarti A Ramanathan, Patrick K Tumwebaze, Oswald Byaruhanga, Thomas Katairo, Victor Asua, Martin Okitwi, Stephen Orena, Jennifer Legac and 9 more

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Systematic in vitro evolution inScience (New York, N.Y.) · 2024
    Article
  3. Antimalarial drug discovery: progress and approaches.Nature reviews. Drug discovery · 2023
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 3 countries.

Oriana KreutzfeldDepartment of Medicine, University of California, San Franciscogrid.266102.1, California, USA.ORCID 0000-0003-2026-345X
Stephanie A RasmussenDominican University of Californiagrid.255148.f, San Rafael, California, USA.
Aarti A RamanathanCenter for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
Patrick K TumwebazeInfectious Diseases Research Collaborationgrid.463352.5, Kampala, Uganda.
Oswald ByaruhangaInfectious Diseases Research Collaborationgrid.463352.5, Kampala, Uganda.
Thomas KatairoInfectious Diseases Research Collaborationgrid.463352.5, Kampala, Uganda.
Victor AsuaInfectious Diseases Research Collaborationgrid.463352.5, Kampala, Uganda.ORCID 0000-0002-0489-4692
Martin OkitwiInfectious Diseases Research Collaborationgrid.463352.5, Kampala, Uganda.
Stephen OrenaInfectious Diseases Research Collaborationgrid.463352.5, Kampala, Uganda.
Jennifer LegacDepartment of Medicine, University of California, San Franciscogrid.266102.1, California, USA.
Melissa D ConradDepartment of Medicine, University of California, San Franciscogrid.266102.1, California, USA.ORCID 0000-0002-9984-8030
Samuel L NsobyaInfectious Diseases Research Collaborationgrid.463352.5, Kampala, Uganda.
Ozkan AydemirBrown Universitygrid.40263.33, Providence, Rhode Island, USA.
Jeffrey BaileyBrown Universitygrid.40263.33, Providence, Rhode Island, USA.
Maelle DuffeyMedicines for Malaria Venture, Geneva, Switzerland.
Brett R BaylesDominican University of Californiagrid.255148.f, San Rafael, California, USA.
Akhil B VaidyaCenter for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
Roland A CooperDominican University of Californiagrid.255148.f, San Rafael, California, USA.
Philip J RosenthalDepartment of Medicine, University of California, San Franciscogrid.266102.1, California, USA.ORCID 0000-0002-7953-7622
Infectious Diseases Research Collaboration · UGUniversity of California, San Francisco · USDominican University of California · USBrown University · USDrexel University · USMedicines for Malaria Venture · CH

Funding

Transmission ProjectU19AI089674 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHEW G DORSEY, MOSES Robert KAMYA · 2010 to 2026
$29.3M
Resistance of Malaria Parasites to Artemisinin-Based TherapiesR01AI075045 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSENTHAL, PHILIP JON · 2009 to 2024
$8.4M
Mechanisms of varied sensitivity of P. falciparum field isolates to the antimalarial drug pipelineR01AI139179 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Philip Jon Rosenthal · 2018 to 2026
$6.3M
Molecular Pathways Affected by Drugs that Disrupt Na+ Homeostasis in Malaria ParasitesR01AI132508 · NIAID · DREXEL UNIVERSITY · PI AKHIL B VAIDYA · 2017 to 2026
$5.7M
Advancing Fast-acting Antimalarials that Disrupt Na+ Homeostasis in ParasitesR01AI154499 · NIAID · DREXEL UNIVERSITY · PI KORTAGERE, SANDHYA, VAIDYA, AKHIL B · 2020 to 2024
$3.7M
HHS | National Institutes of Health (NIH) R01AI075045HHS | National Institutes of Health (NIH) R01AI132508HHS | National Institutes of Health (NIH) U19AI089674Medicines for Malaria Venture (MMV) RD/15/0001NIAID NIH HHS R01 AI075045NIAID NIH HHS R01 AI132508NIAID NIH HHS R01 AI139179NIAID NIH HHS R01 AI154499NIAID NIH HHS U19 AI089674
6 · The paper itself

Abstract

Among novel compounds under recent investigation as potential new antimalarial drugs are three independently developed inhibitors of the Plasmodium falciparum P-type ATPase (PfATP4): KAE609 (cipargamin), PA92, and SJ733. We assessed

Indexed as

AntimalarialsMalaria, FalciparumAdenosine TriphosphatasesDrug ResistanceGenotypeHumansPlasmodium falciparumProtozoan ProteinsUgandaAdenosine TriphosphatasesAntimalarialsProtozoan Proteinscipargamindrug resistanceKAE609malariaPA92PfATP4Plasmodium falciparumSJ733Uganda

Identifiers

PMID34339273
PMCPMC8448140
OpenAlexW3187780962

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.